National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The objective of this study was to evaluate the antimycobacterial activity of Carissa edulis, Sarcocephalus latifolius, and Vitex doniana, three Togolese medicinal plants, used locally for the management of tuberculosis (TB) against Mycobacterium tuberculosis. Hydroethanolic extracts of the roots of C.edulis and S.latifolius, and leaves of V.doniana were obtained by maceration. The in vitro antimycobacterial activity was evaluated using Microplate Alamar Blue Assay (MABA). The phytochemical screening of the extracts was performed on the basis of tests for coloring characteristics to identify the major chemical groups. The hydroethanolic extracts of the leaves of V. doniana and roots of C. edulisand S. latifolius had antimycobacterial activity against M. tuberculosis with minimum inhibitory concentration (MIC) ranging from 312.5-1,250 μg/mL. The best MIC was obtained for the leaves of V. doniana. The extracts of the three plants contain alkaloids, flavonoids, tannins, saponins, and cardiac glycosides except the saponins which are absent in the root of C. edulis. The present study supports the local use of these plants in the management of TB. However, further investigations are needed on isolating and identifying chemical constituents responsible for the observed activity, and also on the toxicity of these plants.
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