National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Fowl adenovirus (FAdV) belongs to Adenoviridae family of genus Aviadenovirus and classified in five species (Fowl aviadenovirus A to E) and 12 serotypes (1 to 8a and 8b to 11). FAdVs cause variety of clinical conditions in poultry and other birds. Hexon, penton base and fiber are three major structural viral proteins of fowl adenovirus. Fiber protein inherits the epitopes, which are specific for determination of subgroup and type of FAdV. It also plays role in viral penetration as it interacts with the host cellular receptors, hence it has role in the pathogenicity of FAdVs. Therefore, analysis of the structure and properties of fiber protein is important in vaccine development. Present study describes the analysis of fiber protein to determine its antigenicity, physico-chemical properties, secondary and tertiary structures. Fiber protein sequence was retrieved from GenBank, NCBI. Secondary and tertiary structure of protein was predicted by using Psipred V4.0 and phyre2 software, respectively. Physical and chemical properties of fiber protein were determined by using ProtParam tool. Antigenicity of fiber protein was determined by using VaxiJen v2.0 server. Total twelve physico-chemical properties of fiber protein were determined and overall antigenicity score of 0.5002 was predicted.
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