An experiment was conducted to study the effect of different feeding regimes on hematological profile of crossbred cows. Study was conducted on 18 crossbred cows which were distributed into three treatment groups comprising of 6 animals in each group. Animals of T₁ (Farmers’ feeding) group were maintained as per the feeding regime followed by small and marginal farmers. Animals of T₂ (Modified feeding) group comprised of feeding with scientific interventions with resources available with farmers. Animals of T₃ (Farm feeding) group were fed as per feeding followed at Livestock Research Station. Average WBC count (10³/µL) was significantly (p<0.05) more in T₃ (7.98±0.12) as compared to T₁ (7.43±0.17) and T₂ (7.52±0.17) groups. Lymphocyte (10³/µL) was maximum in T₃ (3.32±0.07), followed by T₁ (3.24±0.10) and T₂ (3.12±0.09) group but there was no significant difference among treatment groups. Average monocyte (10³/µL) level was significantly higher in T₃ (0.61±0.01) when compared with T₁ (0.57±0.01) and T₂ (0.56±0.01) groups. Granulocyte (10³/µL) was significantly (p<0.05) higher in T₃ (4.05±0.10) as compared to T₁ (3.62±0.11) group. However, the value of T₂ (3.85±0.12) group was at par with T₁ and T₃ groups. Average RBC (10⁶/µL) was significantly (p<0.05) more in T₃ (6.69±0.08) in comparison to T₂ (6.35±0.07) group, whereas, the value of T₁ (6.50±0.07) group was at par with T₂ and T₃ groups. Hb (g/dL) was significantly (p<0.05) higher in T₃ (10.54±0.10) as compared to T₁ (9.50±0.08) and T₂ (9.62±0.10) groups. Average PCV (%) was significantly (p<0.05) higher in T₃ (33.71±0.32) when compared with T₁ (30.04±0.27) and T₂ (30.56±0.35) groups. MCV was 46.73±0.42, 48.32±0.38 and 50.77±0.32 fL in T₁, T₂ and T₃ groups, respectively which differed significantly (p<0.05) among each other. Average of MCH was 14.80±0.17, 15.30±0.13 and 15.77±0.08 pg in T₁, T₂ and T₃ groups, respectively which also differed significantly (p<0.05) among each other. MCHC was 31.63±0.15, 31.52±0.12 and 31.22±0.11 g/dL in T₁, T₂ and T₃ groups, respectively which did not differ significantly among each other. It may be concluded from the present study that WBC, Monocyte, Hb, PCV, MCH and MCHC were significantly (p<0.05) more in T₃ as compared to T₁ and T₂ groups, whereas all the parameters except MCV and MCH in T₁ and T₂ group were at par which shows that modified feeding did not influence hematological profile. Although the health of animals was at par in all treatment groups, production and reproduction performance was different among the treatment groups.

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