The experimental study was conducted on 30 female wistar rats through five groups for 28 days. The group I and III served as control groups. The rats of group IV and V were treated with Acephate and Picrorhiza kurroa and group II was treated with only Acephate. Amongst those, group II and IV showed non-significant reduction in mean body weight and group II, IV and V did not showed any behavioural changes, except, dullness and lethargy. Group II and IV Non-significant variation in mean relative organ weights of liver, kidneys, spleen and Adrenal gland were observed. Grossly, liver and brain showed mild congestion with minimal and focal haemorrhages on kidneys. On histopathology, liver showed focal to multifocal congestion, dilatation of sinusoidal spaces, dilatation of central vein, fatty changes, cytoplasmic rarefication and MNC infiltration. Kidneys revealed mild to moderate congestion, vacuolar, hydropic, cystic degeneration, haemorrhagic cystic degeneration, coagulative necrotic changes, hyaline cast in lumen of exposed tubules and MNC infiltration. There was lymphocyte depletion, minimal to mild congestion in spleen. Neurotoxicity was characterized by vacuolar degeneration and congestion in brain. Intestines revealed acute catarrhal inflammatory changes. Heart showed congestion, minimal to mild haemorrhages and fragmentation. Adrenal glands showed congestion." /> Subacute Toxicity Assessment of Acephate and it’s Amelioration by <em>Picrorhiza kurroa</em> in Female Wistar Rats
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Int.J.Curr.Microbiol.App.Sci.2020.9(12): 3242-3250
DOI: https://doi.org/10.20546/ijcmas.2020.912.386


Subacute Toxicity Assessment of Acephate and it’s Amelioration by Picrorhiza kurroa in Female Wistar Rats
S. A. Londhe*, G. R. Gangane and S. D. Moregaonkar
Department of Veterinary Pathology, College of Veterinary and Animal Sciences, MAFSU, Parbhani, (MS), India
*Corresponding author
Abstract:

The experimental study was conducted on 30 female wistar rats through five groups for 28 days. The group I and III served as control groups. The rats of group IV and V were treated with Acephate and Picrorhiza kurroa and group II was treated with only Acephate. Amongst those, group II and IV showed non-significant reduction in mean body weight and group II, IV and V did not showed any behavioural changes, except, dullness and lethargy. Group II and IV Non-significant variation in mean relative organ weights of liver, kidneys, spleen and Adrenal gland were observed. Grossly, liver and brain showed mild congestion with minimal and focal haemorrhages on kidneys. On histopathology, liver showed focal to multifocal congestion, dilatation of sinusoidal spaces, dilatation of central vein, fatty changes, cytoplasmic rarefication and MNC infiltration. Kidneys revealed mild to moderate congestion, vacuolar, hydropic, cystic degeneration, haemorrhagic cystic degeneration, coagulative necrotic changes, hyaline cast in lumen of exposed tubules and MNC infiltration. There was lymphocyte depletion, minimal to mild congestion in spleen. Neurotoxicity was characterized by vacuolar degeneration and congestion in brain. Intestines revealed acute catarrhal inflammatory changes. Heart showed congestion, minimal to mild haemorrhages and fragmentation. Adrenal glands showed congestion.


Keywords: Acephate, Wistar rats, Picrorhiza kurroa, and Histophological studies
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How to cite this article:

Londhe, S. A., G. R. Gangane and Moregaonkar, S. D. 2020. Subacute Toxicity Assessment of Acephate and it’s Amelioration by Picrorhiza kurroa in Female Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 9(12): 3242-3250. doi: https://doi.org/10.20546/ijcmas.2020.912.386