National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The first line of treatment in Diabetes mellitus includes the use of oral hypoglycemic agents which are associated with several side effects. Herbal agents are known for their effectiveness due to their fewer side effects and relatively low cost. Umbelliferone, a coumarin has been reported to reduce or decrease blood glucose, elevated plasma insulin, protein profile, and cause hypolipidemic effect. Six groups of rats were used as control, diabetic control, umbelliferone at 20 mg/kg b.wt., umbelliferone at 40 mg/kg b.wt. and combination of glibenclamide and umbelliferone at 20 mg/kg b. wt., was used in the study. Diabetes was induced in male Wistar rats and serum estimation of glucose as well as histological study and Immunohistochemical expression of Insulin in islets was evaluated on 15th, 30th and 45th day of experiment. The control rats showed normal body weight values throughout the experimental period. The diabetic rats showed significant hyperglycaemia with reduced body weight and few insulin positive cells. Whereas, the umbelliferone treated groups showed significant decrease in serum glucose levels as well as increase in the body weight profiles by the end of the experimental period. The umbelliferone treated rats showed improvement in morphology of islets of Langerhans and showed increased insulin positive cells Thus, our results show that umbelliferone alone (20mg/kg. b. wt. and 40mg/kg. b. wt.) possessed antihyperglycemic properties. The significant improvement in serum glucose levels and histoarchitecture of the islets of Langerhans with increased insulin positive cellsin the current study could be attributed to bioactivity of umbelliferone and were statistically comparable with the glibenclamide treated group.
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