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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2016: 92.3
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(4): 1060-1065
DOI: https://doi.org/10.20546/ijcmas.2017.604.131


Effect of Filgrastim in a Severe Leucopenia Associated Parvoviral Enteritis in Rottweiler
M.Areshkumar1*, P. Vijayalakshmi1, S. Venkatesa Perumal2 and D. Selvi1
1Department of Veterinary Medicine, Rajiv Gandhi Institute of Veterinary Education and Research, Teaching Veterinary Clinical Campus, Mettupalayam, Puducherry, India
2Department of Veterinary Biochemistry, Rajiv Gandhi Institute of Veterinary Education and Research, Teaching Veterinary Clinical Campus, Mettupalayam, Puducherry, India
*Corresponding author
Abstract:

Filgrastim (Colstim®) is a recombinant Methionyl Human Granulocyte Colony-Stimulating Factor (r-metHuG-CSF) analog used to stimulate the proliferation and differentiation of granulocytes in humans undergoing chemotherapy with granulocyte values below 0.5 G/l likely to be threatened by infections, including sepsis possibly with a fatal outcome. A four month old female Rottweiler pup was presented to the TVCC, RIVER with the history of vomiting and melena for the past two days. Further enquiry revealed that the pup had properly been immunized against all infectious diseases. Clinical examination showed a pink and moist conjunctival mucosa, rectal temperature of 38.7º C, hear rate 150 bpm, and capillary refill time of 3 seconds. The ECG showed a normal study. Laboratory examination revealed Hb - 15.6 g %, PCV - 45.5%, RBC count - 5.87 millions/mm3, WBC count - 1000 cells/ mm3, platelets - 4.21 lakhs/ mm3, MCV - 77.6 fl, MCH - 26.5 pg, MCHC - 34.2%. Absolute count of Neutrophils - 500 cells/ mm3, Lymphocytes - 450 cells/ mm3, Monocytes - 40 cells / mm3 and Eosinophils - 10 cells/ mm3. However, serum biochemistry showed normal values but with an increase in Creatine kinase of 567 U/L. The dog was treated with Filgrastim @ 10 µg/ kg b.wt. S.c along with other supportives. After 5 days of therapy the dog recovered uneventfully.


Keywords: Filgrastim, Leucopenia, Granulocyte colony stimulating factor
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How to cite this article:

Areshkumar, M., P. Vijayalakshmi, S. Venkatesa Perumal and Selvi, D. 2017. Effect of Filgrastim in a Severe Leucopenia associated Parvoviral Enteritis in RottweilerInt.J.Curr.Microbiol.App.Sci. 6(4): 1060-1065. doi: https://doi.org/10.20546/ijcmas.2017.604.131