Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(1): 221-230
DOI: http://dx.doi.org/10.20546/ijcmas.2016.501.020


Down Regulation of MIR-320 Gene Family Members in the Peripheral Blood of Schizophrenia Patients
Tihomir Iliev Vachev, Nikolay Todorov Popov, Vili Krasteva Stoyanova, Hristo Yordanov Ivanov and Danail Savov Minchev
1Department of Plant Phisyology and Molecular Biology, University of Plovdiv Paisii Hilendarski , 24 Tzar Assen Str., Plovdiv, Bulgaria
Department of Pediatrics and Medical Genetics, Medical Faculty Plovdiv, 15A Vassil Aprilov St., 4000 Plovdiv, Bulgaria
University Hospital St. George Plovdiv, 66 Peshtersko Shuse Str., Plovdiv 4000, Bulgaria
State Phsychiatry Hospital Pazardzhik, 28 Bolnichna Str. Pazardzhik, Bulgaria
*Corresponding author
Abstract:

Schizophrenia is a severe disabling brain disease affecting about 1% of the world s population. Due to the dynamic nature of the peripheral blood transcriptome, understanding miRNAs gene expression signature in schizophrenia is a promising tool for discovery of disease-related biomarkers and biological pathways involved. This study aimed to identify specific miRNA signature characteristic for schizophrenia by using genome-wide miRNA expression profiling in patients with schizophrenia vs. healthy controls. In the current study, we examined miRNA gene expression changes applying cust m made LC Science miRNA expression profiling service, by using pooled whole blood-derived total RNA samples in order to evaluate possible miRNAs molecules associated with the disease. Here, we report experimental proof for a differentially down expressed miR-320a, miR- 320b, miR-320d and miR-320c members. To elucidate the biological pathways implicated in schizophrenia, additionally we searched for the validated target genes of miR-320 gene family that might play a role in the regulation of schizophrenia susceptibility genes using miRWalk database. This analysis revealed experimentally validated targets with specific function in nervous system and development including RCOR1, AGO1, REST, and EZH2. Finally, our results suggested that differentially expressed miR-320 family members might be involved in schizophrenia molecular pathways.


Keywords: Schizophrenia, MiRNAs, MiRNA expression profiling, MiRNA microarray assay
Download this article as Download

How to cite this article:

Int.J.Curr.Microbiol.App.Sci. 5(1): 221-230. doi: http://dx.doi.org/10.20546/ijcmas.2016.501.020