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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(10): 3837-3846
DOI: https://doi.org/10.20546/ijcmas.2020.910.441


Haematological Studies on Induced Hyperlipidemia and its Amelioration Using Aged Garlic Extract in Wistar Rats
Shashidhar Ballari1*, M. L. Satyanarayana1, Suguna Rao1, H. D. Narayanaswamy1, Prakash Nadur2 and V. Girishakumar3
1Department of Veterinary Pathology, 3Department of Veterinary Biochemistry, Veterinary College, KVAFSU, Hebbal, Bangalore-560024, India 2Department of Veterinary Pharmacology, Veterinary College, Vinobanagar, Shimogga-577204, India
*Corresponding author
Abstract:

The effect of aged garlic extract on different haematological parameters was studied. The study included 72 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group. To group II high fat diet control was given as diet control. Rats in the group III were administered aged garlic extract at 200mg/kg bw. Group IV rats were administered aged garlic extract at 200mg/kg.bw with high fat diet. Rats in group V were administered atorvastatin at15mg/kg.bw with high fat diet. The group VI rats with aged garlic extract and atorvastatin at half dose (100mg and 7.5mg/kg respectively) with high fat diet. The duration of the study was for 56 days and the blood samples were collected at 42nd and 56th day of study for evaluation.  The high fat diet induced hyperlipidemia altered haematological parameters; significant increase (P<0.05) in the platelet count and increased total leucocyte count. The aged garlic extract treatment showed improvements in the mean(±SE) values of total erythrocyte count, haemoglobin content and moderation of platelet count was seen, this suggested that the aged garlic extract could be used for improving the high fat diet induced haematological abnormalities.


Keywords: High fat diet, Hyperlipidemia, Haematology, Aged garlic extract, Platelet count
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How to cite this article:

Shashidhar Ballari, M.L. Satyanarayana, Suguna Rao, H.D. Narayanaswamy, Prakash Nadur and Girishakumar, V. 2020. Haematological Studies on Induced Hyperlipidemia and Its Amelioration Using Aged Garlic Extract in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 9(10): 3837-3846. doi: https://doi.org/10.20546/ijcmas.2020.910.441