National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Lower limbs ischemia is a life-threatening condition resulting from hypovolemia or vascular occlusion. Peripheral blood mononuclear cells (PBMCs) may represent a novel treatment for ischemia reperfusion injury (IRI).This work was performed to study the effect of PBMCs on induced ischemia /reperfusion in skeletal muscle of adult male albino rat. Fifty adult male albino rats were used; twenty were considered as donors and the others as recipients. The recipients were divided into three groups. Group I served as a control. Group II used for induction of IRI; half of rats was sacrificed immediately (subgroup II-A) and the other half after 4 weeks (subgroup II-B).Group III: IRI induction was done then rats of subgroup III-A were injected with phosphate buffered saline while rats of subgroup III-B were treated by intramuscular injection of PBMCs. Rats of group III were sacrificed after 4 weeks. Muscle samples of all groups were processed for immunohistochemical study and morphological data were statistically analyzed. Rats treated with PBMCs showed well-evidenced repair of the skeletal muscle IRI.
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