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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(10): 1829-1835
DOI: https://doi.org/10.20546/ijcmas.2020.910.223


Effect of Zinc Supplementation on Thyroid and Testosterone Hormone Levels in Wistar Rats
Juneet Kour, J. Devi*, K. Sarma and D. Chakraborty
Division of Veterinary Physiology & Biochemistry, F.V.Sc. and A.H., SKUAST-J, R.S. Pura, Jammu-181102, J&K, India
*Corresponding author
Abstract:

The study was conducted on weaned wistar male rats for the period of 8 weeks from 4 to 12 weeks of age and they were divided into 3 groups as control: rats fed diet without zinc supplementation, Treatment groups, T1 and T2: rats fed diet containing zinc sulphate @ 50mg and 100mg/kg body weight/day, respectively. Blood samples were collected from each rat of all the 3 groups on 6, 8, 10 and 12 weeks of experiment and plasma were separated and triiodothyronine (T3), thyroxine (T4) and testosterone levels were estimated. The plasma concentrations of T3 and T4 in wistar rats increased as age advanced from 6 to 12 weeks in all three groups. The T3 values were varied significantly (P<0.01) with each other in different ages; whereas, T4 levels were recorded significantly higher (P<0.01) at 10 and 12 weeks as compared to 6 and 8 weeks in all groups. Thyroid hormone concentrations were higher in treatment groups (T1 and T2) as compared to control from 8 weeks of age. As compared to control value, in T1 group, T3 concentration was significantly higher (P<0.01) at 8 weeks of age and significantly higher (P<0.01) T4 values were recorded from 10 weeks; whereas, in T2 group, T4 levels were significantly higher (P<0.01) at 10 weeks of age. In between T1 and T2 groups, T3 concentrations were found higher at 8 and 10 weeks and T4 values were higher from 8 to 12 weeks of age in T1 group, but the values were not varied significantly. The plasma concentration of testosterone in all groups showed an increasing trend with the advancing age and the values were varied significantly (P<0.01) within the group at different ages. When compared between the treatment groups and control, significantly higher (P<0.01) values were found in both the treatment groups (T1 and T2) as compared to the values of control group from 8 to 12 weeks of age. The present study revealed earlier rise of testosterone in T1 group as compared to T2 group; however, the values were not varied significantly at different ages studied. The study showed that oral zinc supplementation induces a better testosterone and thyroid hormone profile. The concentrations of the hormones in plasma showed an increasing trend with the advancing age.


Keywords: Age, Testosterone, Thyroid hormones, Wistar rats, Zinc supplementation
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How to cite this article:

Juneet Kour, J. Devi, K. Sarma and Chakraborty, D. 2020. Effect of Zinc Supplementation on Thyroid and Testosterone Hormone Levels in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 9(10): 1829-1835. doi: https://doi.org/10.20546/ijcmas.2020.910.223