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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(3): 97-106
DOI: http://dx.doi.org/10.20546/ijcmas.2016.503.014


Probiotics as a Promising Treatment of Experimental Cryptosporidiosis in an Immuno suppressed Mouse Model
Eman A. Khalifa*
Department of Parasitology, Faculty of Medicine, Taif University, Kingdom of Saudi Arabia
*Corresponding author
Abstract:

Cryptosporidium parvum causes disease both in immune competent and immune compromised people. Probiotics are viable nonpathogenic micro organism that have beneficial effects in the prevention and treatment of pathological condition. The concept of using probiotics therapy has opened up new angles on the role of gut microflora in disease prevention. Lactobacillus casei are commonly found in fermented dairy products such as yogurt which exhibit probiotic properties. The aim of this research was to gain insight into the potential immune modulating effects of lactobacillus casei and yogurt on C. parvum infection in immuno suppressed mice. In this study, seventy mice were used; Sixty mice were immuno suppressed and infected with Cryptosporidium oocysts and ten mice were left immuno competent and not infected. Then, mice were divided into three groups; group (1) was infected and treated with Lactobacillus casei, group (2) was infected and treated with yogurt and group (3) infected and not treated (control). The progress of cryptosporidiosis was assessed by counting oocyst in the stools of mice and developmental stages in histopathological sections of ilea. The results showed that daily administration of yogurt and Lactobacillus casei was able to decrease the parasitic burden in mice as compared with non-treated group. It was observed that the yogurt was more efficient than L. casei as group (2) stopped oocyst shedding earlier than L. casei and also oocyst counts were lower along the duration of experiment as compared with group (1) treated with L. casei. The concept that probiotics could control the development of parasites is promising and hopeful.


Keywords: Probiotics, Cryptosporidiosis, Immuno suppressed mouse.
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How to cite this article:

Eman Khalifa A. 2016. Probiotics as a Promising Treatment of Experimental Cryptosporidiosis in an Immuno suppressed Mouse Model.Int.J.Curr.Microbiol.App.Sci. 5(3): 97-106. doi: http://dx.doi.org/10.20546/ijcmas.2016.503.014