National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Radon (Rn) is a naturally occurring radioactive gas in rocks and soils. The long radioactive decay of uranium forms radon. Radon decays to form radioactive particles that may enter the body through inhalation. Daughter products of radon release high energy alpha particles associated with gamma rays when radon undergoes radioactive decay. It is the second most common cause of lung cancer after smoking. When inhaled with radon gas, high energy ionizing alpha particles are produced from the 222Rn decay. Some of these alpha particles will interfere with biological tissue in the lungs resulting in weakened of cell’s DNA. Everyone is, to some extent, exposed to radon. Cracks in solid floors and under walls, gaps in suspended concrete and wooden floors and round pipe works and crack space, cavities in walls, building joints and small cracks or pores in hollow walls, can lead to radon entry into the building. The genotoxicity of radon gas is addressed primarily to bronchial epithelial and lung parenchyma. Radon comes into the body via the respiratory system. Therefore, the main target of its toxic effects is lung cells, where further decay occurs by emitting ionizing radiation, causing oxidative damage to DNA, proteins, and lipids. Accumulation of such damages in a cell, contribute to malignant transformation. The epigenetic basis of lung cancer is related primarily to changes in the proï¬Âle of microRNA (miRNA). Lung damage associated with radon exposure was attributed to disturbances in miRNA and subsequent protein expression.
Citations |
 |
 |
 |
 |
