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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 1-13
DOI: https://doi.org/10.20546/ijcmas.2020.909.001


Anticholesterolemic, Antitriglyceridemic and Antioxidative Activity Effect of Umbelliferone (Coumarin) in Streptozocin Treated Diabetic Rats
R. Anjan Kumar1*, M. L. Satyanarayana1, H. D. Narayanaswamy1, Suguna Rao1, N. Prakash2 and P. T. Ramesh3
1Department of Veterinary Pathology, 2Department of Veterinary Pharmacology and Toxicology, 3Department of TVCC, Veterinary college, Veterinary college, Hebbal, Bengaluru-560024, India
*Corresponding author
Abstract:

The present study was designed to evaluate the role of umbelliferone in alleviating hyperlipidemia and oxidative damage in streptozotocin induced diabetes mellitus in wistar albino rats. Six groups of rats were used as control, diabetic control, umbelliferone at 20 mg/kg b.wt., umbelliferone at 40 mg/kg b.wt. and combination of glibenclamide and umbelliferone at 20 mg/kg b. wt., was used in the study. Diabetes was induced in male Wistar rats by administering streptozocin at 45 mg/kg b. wt. in citrate buffer, intraperitoneally. Serum estimation of triglyceride and cholesterol as well as anti-oxidant profile such as SOD, CAT and GPx was evaluated on 15th, 30th and 45th day of experiment. The control rats showed normal values throughout the experimental period. The diabetic rats showed significant hypercholesterolemia and hypertriglyceridemia with reduced tissue anti-oxidant levels. Whereas, the umbelliferone treated groups showed significant decrease in triglyceride and cholesterol levels as well as increased the anti-oxidant profiles by the end of the experimental period. Thus, our results show that umbelliferone alone (20mg/kg. b. wt. and 40mg/kg. b. wt.) possessed anticholesterolemic and anti-triglyceridemic properties. The significant improvement in anti-oxidant profile in the current study could be attributed to bioactivity of umbelliferone and were statistically comparable with the glibenclamide treated group.


Keywords: Anticholesterolemic, Antitriglyceridemic and Antioxidative Activity, Umbelliferone
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How to cite this article:

Anjan Kumar, K. R., M. L. Satyanarayana, H. D. Narayanaswamy, Suguna Rao, N. Prakash and Ramesh, P. T. 2020. Anticholesterolemic, Antitriglyceridemic and Antioxidative Activity Effect of Umbelliferone (Coumarin) in Streptozocin Treated Diabetic RatsInt.J.Curr.Microbiol.App.Sci. 9(9): 1-13. doi: https://doi.org/10.20546/ijcmas.2020.909.001