National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The aim of the present study was to determine the phenotypic resistance pattern to β-lactam antibiotics among Escherichia coli clinical isolates and to identify the genetic determinants responsible for β-lactam antibiotic resistance. Forty Escherichia coli isolates were included in this study. Identification of tested strains was confirmed using MALDI-TOF/MS. Phenotypic and genotypic β-lactamase patterns were investigated. Twelve isolates were resistant to carbapenems, while most of them exhibited resistance to the one or more of the third and fourth generation cephalosporins (ESC) (35 out of 40). Phenotypically, the production of extended-spectrum beta-lactamase (ESBL), metallo-β-lactamases (MBL), and carbapenemases was detected in 31, 8, and 15 isolates, respectively. Genotypically, ESBL and carbapenemase encoding genes were detected in 34 and 19 isolates, respectively. The results of the current study indicate the high prevalence of β-lactam resistance among Escherichia coli isolates.
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