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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(8): 2911-2916
DOI: https://doi.org/10.20546/ijcmas.2020.908.325


Dynamism in Resistance Pattern of Escherichia coli -A Drift from Indian Council of Medical Research (ICMR)-Antimicrobial Use Guidelines
V. D. Sathish1*, Guru Prasad Mohanta2, Elizabeth Anna Mathew2 and J. Renga Ramanujam3
 1Department of Pharmacy Practice, KMCH College of Pharmacy, Coimbatore, TamilNadu, India
2Department of Pharmacy, Annamalai University, Chidambaram, Tamil nadu, India
3Department of Microbiology, DR.N.G.P Arts and Science College, Coimbatore,
Tamil Nadu, India
*Corresponding author
Abstract:

Combating Antibiotic resistance has become a great challenge for clinicians due to inappropriate use of antibiotics. Antibiotics once considered being magic bullet is no more having that title. Recommendation in “AMR situation in India by Department of Biotechnology (DBT)” and “Treatment Guidelines for Antimicrobial Use by Indian Council of Medical Research (ICMR) India” emphasized the need for regional surveillance starting from the level of state to an individual hospital has been motivation behind the study. Three hospitals in region of Cuddalore in Tamilnadu (India) have been the source of specimen for isolation of Escherichia coli during the period of January to July 2019. Antibiogram reports were collected during the study period and utilized for the study. Among 124 isolates Urine, High vaginal swab, Pus, Serum, Oral swab and Amniotic fluid occupied 81.45%(n-101), 08.06%(n-10), 5.64%(n-7), 2.41%(n-3), 1.62%(n-2) and 0.81% (n-1) respectively. Antibiogram for the Escherichia coli isolates revealed 90% of resistance to Cefepime, 68% to Ciprofloxacin, 50% to Tetracyclin, 30% to Meropenem etc., Similarly high percentage of sensitiveness was evident in Cefotaxime (95.94%), Imipenum (95.91%), Piperacillin/Tazobactem (86%), Meropenem (70%) etc. On comparison with the 2014 ICMR (Antimicrobial Susceptibility) data percentage of resistance and susceptibility has a drastic change both in resistance and sensitivity. From the study it is clear that the generic recommendations on antibiotic use at national level can’t be a desirable solution or recommendations to clinicians. The study signifies the importance of local surveillance and infection control programs.


Keywords: Antibiotics, Treatment, Surveillance, Escherichia coli, Resistance, Meropenem, Sensitivity
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How to cite this article:

Sathish, V. D., Guru Prasad Mohanta, Elizabeth Anna Mathew and Renga Ramanujam, J. 2020. Dynamism in Resistance Pattern of Escherichia coli -A Drift from Indian Council of Medical Research (ICMR)-Antimicrobial Use Guidelines.Int.J.Curr.Microbiol.App.Sci. 9(8): 2911-2916. doi: https://doi.org/10.20546/ijcmas.2020.908.325