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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(8): 2330-2336
DOI: https://doi.org/10.20546/ijcmas.2020.908.267


Pharmacological Evaluation of Xanthoxylum oxyphyllum Edgew Extract with Special Reference to Anti-inflammatory Activity
Jayant Chatterjee1, Pritam Mohan1 and Manisha Dutta2*
1Department of Pharmacology and Toxicology, College of Veterinary Sciences, Assam Agricultural University, Khanapara, Assam, India
2Department of Food Science and Nutrition, College of Community Science, Assam Agricultural University, Jorhat, Assam, India
*Corresponding author
Abstract:

Inflammation is a localized physical condition, the immune reaction of the body tissues towards the harmful stimuli such as pathogens, damaged cells or irritants. Steroids and some other drugs have been used to alleviate inflammation but its regular use has been discouraged by the practitioners. The use of this plant in NE India is diverse but few pharmacological studies have been carried out to evaluate its anti-inflammatory activity. Therefore, the present study is undertaken to evaluate the anti-inflammatory properties of Xanthoxylum oxyphyllum. For evaluation of anti-inflammatory properties of the ethanolic extract of X. oxyphyllum, carrageenan induced rat paw edema model was used. Three doses of the extract showed significant reduction of paw edema in the later stages of carrageenan induced inflammation. Medium dose @30 mg/kg has shown maximum inhibition of paw volume edema. This might be due to inhibition of synthesis and/or release of inflammatory mediators in the late phase of inflammation. The ethanolic leaf extract of Xanthoxylum oxyphyllum, was evidenced to possesses anti-inflammatory properties but however, better activity was seen with medium dose @ 30 mg/kg body weight in both carrageenan induced paw edema model and Adjuvant Induced Arthritis model.


Keywords: Anti-inflammatory activity, Ethanolic extract, Pharmacology, Wister rats and mice, Xanthoxylum oxyphyllum
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How to cite this article:

Jayant Chatterjee, Pritam Mohan and Manisha Dutta. 2020. Pharmacological Evaluation of Xanthoxylum oxyphyllum Edgew Extract with Special Reference to Anti-inflammatory Activity.Int.J.Curr.Microbiol.App.Sci. 9(8): 2330-2336. doi: https://doi.org/10.20546/ijcmas.2020.908.267