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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(8): 125-134
DOI: https://doi.org/10.20546/ijcmas.2020.908.013


Pathological Evaluation of Anti-tumour Effects of Withaferin A against Experimentally Induced Mammary Tumour in Rats
Pratheepa*, C. Balachandran and R. Sridhar
Department of Veterinary Pathology, Madras Veterinary College, TANUVAS,
Chennai- 600 007, India
*Corresponding author
Abstract:

With the aim to explore the anti-tumour effect of Withaferin A in DMBA (7,12-dimethylbenz[a]anthracene) induced mammary tumour in rats, seventy two female Sprague-Dawley rats were equally distributed to control, DMBA, tamoxifen and Withaferin A groups. Tamoxifen, which is widely used as first-line drug in the treatment of estrogen positive breast cancer was taken as standard for comparison. The study was conducted for a period of 16 weeks. DMBA (5 mg/rat/week/per os) at 4 weekly doses were used for tumour induction. Piloerection was noticed after DMBA administration. Tumour latency, location, incidence, frequency, size, volume and weight were recorded. Hundred per cent tumour formation in DMBA alone administered animal was observed. No metastasis was recorded. Abdominal glands were most frequently affected in all DMBA administered groups. Withaferin A group showed 17% tumour inhibition and the number of tumours were almost equal to that of DMBA group. Higher incidence of carcinomas (65%) and lower incidence of benign (35%) mammary tumours were observed in Withaferin A group with maximum tumour frequency of seven tumours/rat when compared with tamoxifen group. Hence further investigations are required.


Keywords: DMBA, Mammary tumours, Pathology, Rats, Tamoxifen, Withaferin A
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How to cite this article:

Pratheepa, K., C. Balachandran and Sridhar, R. 2020. Pathological Evaluation of Anti-tumour Effects Withaferin A against Experimentally Induced Mammary Tumour in Rats.Int.J.Curr.Microbiol.App.Sci. 9(8): 125-134. doi: https://doi.org/10.20546/ijcmas.2020.908.013