National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Etanercept is an anti-TNFα biopharmaceutical used in the treatment of several disorders of inflammation as well as autoimmune conditions. This present study was aimed to identify the skin sensitization potential of the etanercept, in guinea pigs by following Guinea Pig Maximization Test (GPMT) of Magnusson and Kligman method. The animals were divided into two groups; negative control comprising six males and 6 females and treatment groups having ten males and ten females. Through a range finding study, the dose for main study was selected as 0.5% (low concentration) and 1.0% (high concentration) of etanercept for topical induction and challenge doses. The application site was examined at 48 and 72 hours post-dosing for the presence of allergic reactions. Apart from this, animals were observed for body weight and exhibition of clinical signs of toxicity daily throughout the experimental period. At both time points of observation, no skin reaction was observed in the experimental group after the challenge. The body weights of the treated animals were found to be comparable with the control animals. Based on the results of the study, the etanercept was found to be safe and well tolerated and was concluded to be a non- sensitizer to the skin of the guinea pigs.
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