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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(7): 3832-3839
DOI: https://doi.org/10.20546/ijcmas.2020.907.448


Evaluation of CD68 in Oral Squamous Cell Carcinoma and their Relation with Clinicopathological Parameters –An Immunohistochemical Study
Ahlam T. Bdewi1, Ahmed A. Alkadir Mohamed Labib2, Ban F. AL Drobie3, Bashar H. Abdullah3 and Museedi Omar3
1Department of Oral Diagnosis/ College of Dentistry /Al Anbar University,Iraq
2Department of Clinical Oncology/, Clinical Oncologist, Al-Amal Hospital, Baghdad, Iraq
3Department of Oral Diagnosis/ Oral Pathology, College of Dentistry,Baghdad University, Iraq
*Corresponding author
Abstract:

Macrophages are important cells for the innate immunity. Circulating monocytes are attracted to tissues by chemotactic factors and become macrophages under the influence of their microenvironment. Several studies have shown that macrophages are important to the prognosis of patients with different types of cancer. The aim of this study was to evaluate the expression of CD68 in OSCC patients and to investigate the possible relationship of macrophages using CD68 in various histopathological grades, stages and other clinical parameters of OSCC. preoperative diagnosed specimens (n=30)were processed for immunohistochemistry to detect CD68 positive cells. Expression of macrophages was semiquantitatively analyzed. Immunohistochemical study show expression of CD68 in all specimens. A significant correlation between CD68 infiltration and gender of patients was found,where it high in females than males. Other clinicopathological findings of OSCC show non-significant correlation. Immunohistochemical expression of CD68 were observed in all studying samples of oral squamous cell carcinoma. however, statistically non-significant correlation was found between the mean expression level of these infiltrates macrophages with clinicopathological findings of OSCC expect with Gender.


Keywords: Oral Squamous Cell Carcinoma, CD68 Immuno-histochemical Study
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How to cite this article:

Ahlam T. Bdewi, Ahmed A. Alkadir Mohamed Labib, Ban F. AL Drobie, Bashar H. Abdullah and Museedi Omar. 2020. Evaluation of CD68 in Oral Squamous Cell Carcinoma and their Relation with Clinicopathological Parameters – An Immunohistochemical Study. Int.J.Curr.Microbiol.App.Sci. 9(7): 3832-3839. doi: https://doi.org/10.20546/ijcmas.2020.907.448