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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(7): 3533-3537
DOI: https://doi.org/10.20546/ijcmas.2020.907.412


Therapeutic Effect of Idivallathi mezhugu on Lipid Peroxidation and Antioxidant System in 7, 12-dimethylbenz[a]anthracene Induced Mammary Tumour in Female Sprague-Dawley Rats
S.Sabidha1*, C. Balachandran2, R. Sridhar3 and A. Raja4
1Veterinary Assistant Surgeon, Pudukkottai, India
2TANUVAS, Chennai, India
3Department of Veterinary Pathology, TANUVAS, Madras Veterinary College, Chennai, India
4Education Cell, TANUVAS, VCRI, Namakkal, India
*Corresponding author
Abstract:

The study was undertaken for 150 days on female Sprague-Dawley rats to evaluate antioxidant effects on DMBA induced mammary tumours. A total of 80 rats were randomly allotted to 5 groups with 18 rats in 4 groups and 12 rats to the control group distributed to DMBA, DMBA + Tamoxifen and DMBA + Idivallathi mezhugu (IM) and IM groups. Rats were administered with 4 weekly doses of 5 mg DMBA/rat in olive oil by oral gavage beginning at 42nd day of age. From the day of first dosing of DMBA, tamoxifen (100 µg/kg/ BW/Day) was given in gingelly oil to DMBA + Tamoxifen group and IM (300 mg/kg BW/daily) in palm jaggery to DMBA+IM and IM groups by oral gavage till the end of study. DMBA group showed significant (P<0.05) increase in lipid peroxidation and antioxidants catalase (CAT) and superoxide dismutase (SOD) levels besides reduced glutathione (GSH). Whereas, IM and tamoxifen treated groups did not show any significant difference in lipid peroxidation and oxidative stress with no increase in the antioxidant level compared to the control. Selective growth advantage of tumour cells over their surrounding normal counterpart was evident in the DMBA group and inhibited lipid peroxidation and oxidative stress was evident in the IM group.


Keywords: Antioxidant, IM, DMBA, Lipid peroxidation, Mammary carcinogenesis
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How to cite this article:

Sabidha, S., C. Balachandran, R. Sridhar and Raja, A. 2020. Therapeutic Effect of Idivallathi mezhugu on Lipid Peroxidation and Antioxidant System in 7, 12-dimethylbenz[a]anthracene Induced Mammary Tumour in Female Sprague-Dawley Rats.Int.J.Curr.Microbiol.App.Sci. 9(7): 3533-3537. doi: https://doi.org/10.20546/ijcmas.2020.907.412