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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(7): 2906-2922
DOI: https://doi.org/10.20546/ijcmas.2020.907.343


Effect of Resiniferatoxin as an Anti-Inflammatory Drug on Experimental Trichinellosis
Doaa A.A. Balaha1*, Howaida I. H. Ismail1, Omnia M. K. Risk2 and Ghada A. M. Gamea1
1Department of Medical Parasitology, Faculty of Medicine, Tanta University, Tanta, Egypt
2Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt Tanta  University, Tanta, Egypt
*Corresponding author
Abstract:

Trichinellosis is a parasitic disease causing a harmful inflammatory response. Corticosteroids are used as anti-inflammatory drugs but cause immune-suppression. The present study evaluated the anti-inflammatory effect of resiniferatoxin (RTX), a TRPV1 receptor agonist as an adjuvant therapy with albendazoleon the early and late stages of experimental trichinellosis in comparison with cortisone. The effect of RTX was evaluated by determination of the total larval count in the skeletal muscles, degree of inflammation in intestine and muscles and and the determination of the serum level of interferon gamma (IFN-γ) and inducible nitric oxide synthase (iNOS) by ELISA. Our results showed that treatment with (albendazole and RTX) significantly decreased the total larval count and the inflammation in both the intestinal and the musclar phases in comparison with other groups. In addition, RTX decreased the serum levels of IFN-γ and iNOS. We concluded that RTX has valuable anti-inflammatory and immuno-modulatory effects against T. spiralis infection and is beneficial for the treatment of trichinellosis as compared to cortisone.


Keywords: Trichinella spiralis, Resiniferatoxin, Cortisone, Inflammation, IFN-γ and iNOS
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How to cite this article:

Doaa A.A. Balaha, Howaida I. H. Ismail, Omnia M. K. Risk and Ghada A. M. Gamea. 2020. Effect of Resiniferatoxin as an Anti-Inflammatory Drug on Experimental Trichinellosis.Int.J.Curr.Microbiol.App.Sci. 9(7): 2906-2922. doi: https://doi.org/10.20546/ijcmas.2020.907.343