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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(7): 3207-3215
DOI: https://doi.org/10.20546/ijcmas.2020.907.374


Vitamin C Moderates the Oxidative Stress of Bubaline Pediculosis in Indian Water Buffaloes
E. Madhesh1*, Umesh Dimri1, Y. Ajith1, S. Shanmuganathan2, P. Sivasankar2 and R. Karthikeyan3
1Division of Medicine,
2Division of Microbiology,
3Division of Biochemistry, Indian Veterinary Research Institute, Izatnagar, UP, 243122, India
*Corresponding author
Abstract:

Bubaline pediculosis caused by the sucking lice, Haematopinus tuberculatus is a widespread and economically important ectoparasitic infestation of Indian water buffaloes. This lice infestation in buffalo is characterized by anemia, mineral imbalance and loss of performance but its pathobiology is unexplored. The aim of the present study was to investigate the oxidative pathobiology of bubaline pediculosis and its alleviation through the commonly used two antioxidants as an supportive therapy (N- acetyl cysteine and vitamin C). Twenty four Indian dairy buffaloes with severe bubaline pediculosis were allotted to the three groups (Group 1, 2 and 3).Another eight healthy animals free of any clinical anomalies and ectoparasites have been included as healthy controls (Group 4). Sucking lice infested animals (Group 1, 2 and 3) animals were given with single dose of ivermectin therapy @ 200 microgram/kg body weight Subcutaneously; In addition, group 2 and group 3 animals were treated with N-acetyl cysteine @ 12 mg/kg body weight and vitamin C@2g/ per animal po, respectively, once daily for 15 days. Before therapy (Day 0) and post-therapy (Day 28), haematological parameters like total erythrocyte count (TEC),haemoglobin (Hb), total leukocyte count (TLC) and Differential leukocyte count (DLC), and oxidative stress parameters like total antioxidant capacity( TAC), lipid peroxidation (LPO), reduced glutathione (GSH), and superoxide dismutase (SOD) were evaluated on sucking lice infested buffaloes. Sucking lice infestation in Indian water buffaloes has showed severe anaemia, leukocytosis and along with remarkable oxidative stress response. Vitamin C given animals have demonstrated improved recovery from the bubaline pediculosis induced oxidative stress and reached normalcy post-therapeutically. Adjunct therapy of Vitamin C along with subcutaneous ivermectin has alleviated pathological damage in water buffaloes and hastened clinical recovery, while N-acetyl cysteine has been less effective in alleviating the oxidative stress. In future, therapeutic antioxidant studies should address the influence of the oxidative stress response in the host biological system.


Keywords: Vitamin C, Bubaline pediculosis, Oxidative stress response, N-acetyl cysteine, Sucking lice
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How to cite this article:

Madhesh, E., Umesh Dimri, Y. Ajith, S. Shanmuganathan, P. Sivasankar and R. Karthikeyan. 2020. Vitamin C Moderates the Oxidative Stress of Bubaline Pediculosis in Indian Water Buffaloes.Int.J.Curr.Microbiol.App.Sci. 9(7): 3207-3215. doi: https://doi.org/10.20546/ijcmas.2020.907.374