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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(6): 4236-4246
DOI: https://doi.org/10.20546/ijcmas.2020.906.497


Pharmacokinetics of Ivermectin (Noromectin®) Following Single Dose Subcutaneous Administration in Sheep
S. Sakthikarthikeyan*, A.H. Ahmad and K. Kannan
Department of Veterinary Pharmacology and Toxicology, Govind Ballabh Pant University of Agriculture and Technology, College of Veterinary and Animal Sciences, Pantnagar-263145, (Uttarakhand), India
*Corresponding author
Abstract:

The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Noromectin®) 0.2 mg/kg b.wt in Sheep.   The study was conducted in four adult, indigenous male muzzafarnagari sheep (1.5- 2.5 yrs in age, weighing 23±2 kg). The plasma concentration of ivermectin was determined by HPLC. The decay in plasma concentration of drug was biexponential in sheep. The Cmax value of 17.5 ng/ml was obtained at Tmax of 3.3 days in sheep, following SC administration of Noromectin®. The elimination half life (β_HL), volume of distribution (V1_F) and AUC were calculated as 6.4 days, 4.19 L.kg-1, 159.3 day.ng/mL in sheep , following SC administration of Noromectin®. A dosage regimen of 0.2 mg/kg at 7 days interval is recommended in sheep.


Keywords: Ivermectin, Pharmaco-kinetics, Subcutaneous
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How to cite this article:

Sakthikarthikeyan, S., A.H. Ahmad and Kannan, K. 2020. Pharmacokinetics of Ivermectin (Noromectin®) Following Single Dose Subcutaneous Administration in Sheep.Int.J.Curr.Microbiol.App.Sci. 9(6): 4236-4246. doi: https://doi.org/10.20546/ijcmas.2020.906.497