National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Noromectin®) 0.2 mg/kg b.wt in Sheep. The study was conducted in four adult, indigenous male muzzafarnagari sheep (1.5- 2.5 yrs in age, weighing 23±2 kg). The plasma concentration of ivermectin was determined by HPLC. The decay in plasma concentration of drug was biexponential in sheep. The Cmax value of 17.5 ng/ml was obtained at Tmax of 3.3 days in sheep, following SC administration of Noromectin®. The elimination half life (β_HL), volume of distribution (V1_F) and AUC were calculated as 6.4 days, 4.19 L.kg-1, 159.3 day.ng/mL in sheep , following SC administration of Noromectin®. A dosage regimen of 0.2 mg/kg at 7 days interval is recommended in sheep.
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