National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was undertaken to evaluate the pharmacokinetics of Ivermectin (Ivomec super®) 0.2 mg/kg b.wt in cattle calves. The study was conducted in four cross-bred male cattle calves (1.0-1.5 yrs in age, weighing 110±5 kg). The plasma concentration of ivermectin was determined by HPLC. The decay in plasma concentration of drug was biexponential in cattle calves. The Cmax value of 33.38 ng/mL was obtained at Tmax of 4.49 days in cattle calves, following SC administration of Ivomec super ®. The elimination half life (β_HL), volume of distribution (V1_F) and AUC were calculated as 24.59 days, 2.28 L.kg-1, 393.9 day.ng/mL in cattle calves , following SC administration of Ivomec super ®. A dosage regimen of 0.2 mg/kg at 14 days interval is recommended in cattle.
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