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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(6): 2381-2389
DOI: https://doi.org/10.20546/ijcmas.2020.906.292


Intriguing Role of Lysophosphatidic Acid (LPA) and its Receptor Mediated Signaling during Implantation: A Review
B. Madhumitha1, D. Reena2 and S. Manokaran3*
1Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai – 600 007, India
2Department of Clinics, Madras Veterinary College, TANUVAS, Chennai – 600 007, India
3Kangayam Cattle Research Station, TANUVAS,
Uppupallam, Baguthampalayam, Sathyamangalam – 638 451, India
*Corresponding author
Abstract:

Regardless of major advances in medical technologies many Assisted Reproductive Technology (ART) experience recurrent implantation failures (RIF). Lysophosphatidic acid (LPA) signaling cross talks between the mother and the implanted embryo at a very early stage of gestation to enhance endometrium receptivity. LPA is a simple water soluble phospholipid that arbitrates varied biological functions like proliferation, migration and activation of various intracellular signaling pathways in diverse cell types. LPA also has a chief role to play in human and animal reproductive processes including luteolysis, endometrium and ovarian function, estrous cycle regulation, embryo development and implantation, placentation and decasualization with the help of receptor (LPAR1-6) mediated LPA signaling. Further, autotaxin a LPA producing enzyme is found to be upregulated during decasualization of human endometrial stromal cells (HESC). LPA aids in the maintenance of endometrium receptivity by invigorating the expression of prostaglandin endoperoxide synthase 2 (PTGS2). LPA also increases progesterone (P4) and prostaglandin E2 (PGE2) secretion and elevation in PGE2/PGF2α ratio. This review highlights and discusses about the current advancement in receptor mediated LPA signaling in human reproduction, ruminant reproduction pointing to bovine and sheep models, and even in porcine reproduction models and correlating it with human reproductive function.


Keywords: Lysophosphatidic acid (LPA), Assisted Reproductive Technology (ART), Recurrent implantation failure (RIF), Autotaxin
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How to cite this article:

Madhumitha. B., D. Reena and Manokaran. S. 2020. Intriguing Role of Lysophosphatidic Acid (LPA) and its Receptor Mediated Signaling during Implantation: A Review.Int.J.Curr.Microbiol.App.Sci. 9(6): 2381-2389. doi: https://doi.org/10.20546/ijcmas.2020.906.292