National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Regardless of major advances in medical technologies many Assisted Reproductive Technology (ART) experience recurrent implantation failures (RIF). Lysophosphatidic acid (LPA) signaling cross talks between the mother and the implanted embryo at a very early stage of gestation to enhance endometrium receptivity. LPA is a simple water soluble phospholipid that arbitrates varied biological functions like proliferation, migration and activation of various intracellular signaling pathways in diverse cell types. LPA also has a chief role to play in human and animal reproductive processes including luteolysis, endometrium and ovarian function, estrous cycle regulation, embryo development and implantation, placentation and decasualization with the help of receptor (LPAR1-6) mediated LPA signaling. Further, autotaxin a LPA producing enzyme is found to be upregulated during decasualization of human endometrial stromal cells (HESC). LPA aids in the maintenance of endometrium receptivity by invigorating the expression of prostaglandin endoperoxide synthase 2 (PTGS2). LPA also increases progesterone (P4) and prostaglandin E2 (PGE2) secretion and elevation in PGE2/PGF2α ratio. This review highlights and discusses about the current advancement in receptor mediated LPA signaling in human reproduction, ruminant reproduction pointing to bovine and sheep models, and even in porcine reproduction models and correlating it with human reproductive function.
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