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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(5): 3052-3060
DOI: https://doi.org/10.20546/ijcmas.2020.905.363


Effect of Sida cordata (Burm.F.) Borss Extracts on Oral Cancer: An in vitro Study
R. Gulnaz1* and Sneha S. Vijayashekar2
1Department of Biochemistry, 2Department of Oral Pathology and Microbiology Farooqia Dental College & Hospital Mysore, Karnataka, India
*Corresponding author
Abstract:

Natural components of the plants, animals and mineral sources are used as medicines since ancient time as they have fewer or no side effects, plant products have been widely used in controlling cancer as complementary to synthetic medicine is gaining increased popularity. Present study was carried out with different extract of leaf, stem, root and the whole plant of Sida cordata (burm.f.) Borss (SC) to determine their probable anticancer/ antiproliferative effect on oral cancer using Human tongue squamous cell carcinoma (CAL-27) cell lines and normal human gingival fibroblast (HGF) cell lines in comparison with commonly used standard drug Cisplatin. Among the various extracts used in the study, leaf extracts significantly reduced the cell viability, Highest inhibition was recorded in the ethanol extract (87.5%) followed by water (85%) at 200µg/min the MTT assay carried out. Further TUNEL assays revealed that SC extracts induces the apoptosis.


Keywords: Antiproliferative, Apoptosis, Human tongue squamous cell carcinoma
(CAL-27)
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How to cite this article:

Gulnaz, A. R. and Sneha S. Vijayashekar. 2020. Effect of Sida cordata (Burm.F.) Borss Extracts on Oral Cancer: An in vitro Study.Int.J.Curr.Microbiol.App.Sci. 9(5): 3052-3060. doi: https://doi.org/10.20546/ijcmas.2020.905.363