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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(4): 1800-1808
DOI: https://doi.org/10.20546/ijcmas.2020.904.211


Effects of Medetomidine-Ketofol Anaesthesia on Clinico-Physiological and Haemato-Biochemical Parameters in Goats
A. S. Sengar, S. K. Tiwari and Rukmani Dewangan*
Department of Veterinary Surgery and Radiology, College of Veterinary Science, Anjora, Durg (C.G.), India
*Corresponding author
Abstract:

The study was conducted on six healthy non-descript goats of either sex weighing between 20-25 kg by administrating atropine sulphate (0.04 mg/kg I/M) followed by medetomidine (10 µg/kg I/M) and 15 min. later followed by induction of anaesthesia with ketofol (5mg/kg I/V). After medetomidine administration, lowering of head was observed in all the animals within 4.20±0.33 min. After ketofol injection, there was rapid and smooth onset of anaesthesia (0.550.15 min). There was marked sedation with protrusion of tongue from buccal cavity, profuse salivation was noticed. Eyes remained partially closed throughout anaesthesia. The corneal and palpebral reflexes were abolished within 3 min. The anal pinch reflex was abolished completely. Muscle relaxation was excellent. The duration of anaesthesia was 85.42 ± 2.31 min. and lasted by raising of head. The recovery was smooth, free from excitement which occurs within 132.85 ± 3.24 min. A significant (P<0.05) decrease in heart rate and respiration rate was observed up to 20 min. and 60 min. respectively whereas rectal temperature showed slight variation. There was non-significant decrease in Hb, PCV and TLC. Neutrophils showed significant (P>0.05) increase with significant (P<0.05) decrease in lymphocyte count at 60 min. There was significant (P>0.05) increase serum glucose level upto 60 min. with non-significant variation in serum urea nitrogen, creatinine AST and ALT. All the physio-haemato-biochemical parameters changes remained within physiological range. Therefore, it is concluded that medetomidine-ketofol provides adequate anaesthesia with smooth and rapid recovery without any deleterious effects on vital organs. Hence, Ketofol can be safely used as general anaesthesia in goats for longer duration.


Keywords: Anaesthesia, Atropine sulphate, Clinico-physiological, Goat, Haemato-biochemical, Ketofol, Medetomidine
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How to cite this article:

Sengar, A. S., S. K. Tiwari and Rukmani Dewangan. 2020. Effects of Medetomidine-Ketofol Anaesthesia on Clinico-Physiological and Haemato-Biochemical Parameters in Goats.Int.J.Curr.Microbiol.App.Sci. 9(4): 1800-1808. doi: https://doi.org/10.20546/ijcmas.2020.904.211