National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Trichomonas vaginalis (T. vaginalis) is a common health problem all over the world. The present study aimed to determine the prevalence rate and risk factors of T. vaginalis in females in Menoufia Governorate, Egypt and assess some immunological parameters includingIL-2, IL-17, IL22 and INFᵧ and their relation to cytopathological changes in asymptomatic and symptomatic T. vaginalis infected females. Two hundred females aging between 18 and 50 years' old were classified into two groups: Group I: Asymptomatic females subdivided into subgroup I a (non-infected) from which control subgroup were selected and I b (infected).Group II: Symptomatic females was subdivided into subgroup II a (non-infected) and II b (infected).The groups were screened for T.vaginalis by direct wet mount, Giemsa, Acridine orange (AO) and Papanicolaou (Pap) stained vaginal smears and culture technique. Cytopathological examination was done by using pap smears. Immunological detection of vaginal IL-2, IL-17, IL-22 and IFNγ were assessed using enzyme linked immunosorbent assay (ELISA). The results revealed that the prevalence rate of T. vaginalis was 22.5% (45/200) among the studied participants as proved by culture method, 25% (25/100) in asymptomatic females and 20% (20/100) in symptomatic females. There were significant elevated levels of IL-2, IL-17, IL-22 and IFN-γ in asymptomatic infected subgroup(Ib) than symptomatic infected subgroup (IIb) and control subgroup and decrease in cytopathological changes including halo cells, reactive nuclear changes and ghost cell. Elevated cytokines play a protective effect in asymptomatic T.vaginalis infected females proved by histopathological inflammatory reaction and decrease symptoms in these females.
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