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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(4): 525-532
DOI: https://doi.org/10.20546/ijcmas.2020.904.063


Hematological Alterations in Cisplatin Induced Toxicity in Rats and Its Amelioration by Andrographis paniculata
T. Rajendrakumar1*, Suguna Rao1, M. L. Satyanarayana1, H. D. Narayanaswamy1, S. M. Byregowda2 and N. B. Shridhar3
1Department of Veterinary Pathology, Veterinary College, KVAFSU, Hebbal, Bangalore-560024, India
2Institute of Animal Health and Veterinary Biologicals, KVAFSU, Bangalore, India
3Department of Veterinary Pharmacology, Veterinary College, Vinobanagar, Shimogga-577204, India
*Corresponding author
Abstract:

Cisplatin (CP) is considered one of the most effective and widely used anti-neoplastic drug in the treatment of different solid organ tumors. The present study was carried out to assess the hematological changes following CP administration in Wistar albino rats and its amelioration by extract of Andrographis paniculata (AP). The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP 15 days prior to CP administration and followed by AP treatment for 45 days. Rats in group V were administered with CP and concurrently treated with AP extract at 500mg/kg by oral gavaging for 45 days. The CP treated rats showed significant decrease in haemoglobin, TEC, TLC and platelet count as compared to normal control animals. Supplementation of AP to CP treated rats significantly improved the hematological parameters. The study concluded that damage to the hemopoietic system evident by deranged hematological parameters can be prevented by administration of extract of Andrographis paniculata.


Keywords: Andrographis paniculata, Wistar Albino rats, Hematological parameters
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How to cite this article:

Rajendrakumar, T., Suguna Rao, M. L. Satyanarayana, H. D. Narayanaswamy, S. M. Byregowda and Shridhar, N. B. 2020. Hematological Alterations in Cisplatin Induced Toxicity in Rats and Its Amelioration by Andrographis paniculata.Int.J.Curr.Microbiol.App.Sci. 9(4): 525-532. doi: https://doi.org/10.20546/ijcmas.2020.904.063