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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(3): 1998-2011
DOI: https://doi.org/10.20546/ijcmas.2020.903.232


Assessment of Susceptibility towards iAs Induced Carcinogenesis in West Bengal, India
Archismaan Ghosh, Apurba Mukherjee, Sutapa Mukherjee and Madhumita Roy*
Department Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata, India
*Corresponding author
Abstract:

Inorganic Arsenic (iAs) contamination of groundwater had been a major health hazard. In West-Bengal, many areas had been found to have high level of iAs in groundwater. Chronic exposure to iAs may lead to the generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). This results in DNA damage, inflammation, impairment of repair activity, thereby culminating in carcinogenesis. Higher telomerase activity may be another manifestation of iAs exposure. This is a pilot study involving 15 subjects residing in an arsenic endemic area of West-Bengal. Accumulation of iAs was tested in the nail, hair and blood samples of these individuals. Extent of ROS, RNS, DNA damage, expression of repair enzymes and status of pro-inflammatory cytokines had been studied. Telomerase activity and NF-κB were also studied. 15 samples were collected from subjects residing in an area having iAs within safe limits. It was observed that in samples from iAs endemic region, ROS and RNS generation was high, followed by DNA damage. These individuals showed higher telomerase activity compared to the control. Status of NF-κB and pro-inflammatory cytokines had been found to be elevated in comparison to the control. Therefore, these parameters could assess the susceptibility of these individuals towards carcinogenesis.


Keywords: Arsenic, ROS, carcinogenesis, cytokines, telomerase, DNA repair, NF-κB
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How to cite this article:

Archismaan Ghosh, Apurba Mukherjee, Sutapa Mukherjee and Madhumita Roy. 2020. Assessment of Susceptibility towards iAs Induced Carcinogenesis in West Bengal, India.Int.J.Curr.Microbiol.App.Sci. 9(3): 1998-2011. doi: https://doi.org/10.20546/ijcmas.2020.903.232