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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(3): 954-961
DOI: https://doi.org/10.20546/ijcmas.2020.903.112


Preparation of Recipient Wound Bed by Platelet Rich Plasma for Skin Flaps in Dogs
M. Gokulakrishnan1*, L. Nagarajan2 and C. R. Ramani2
1Department of Clinics, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Tamil Nadu, India
2Department of Veterinary Surgery and Radiology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Tamil Nadu, India
*Corresponding author
Abstract:

Open wound management, until the wound is considered suitable for reconstruction or until it has healed by second intention, has been the treatment of choice for centuries. The aim of wound healing is to promote rapid wound closure and prevent excess scar formation. Application of platelet rich plasma remain a viable option for enhancing the granulation tissue formation and early wound bed preparation before large wounds could be reconstructed with skin flaps. The flaps performed in the present study were flank and elbow rotational flap, transposition flap, caudal superficial epigastric flap, single and bipedicle advancement flaps. The flaps were selected based on the location and site of the wound. Subjective evaluation of wound healing based on the physical observations, clinical photography, wound planimetry studies were evaluated. Additionally, hematological, bacteriological, biochemical, and histopathological evaluation were done for the recipient wound bed and skin flap. A subjective analysis of vascularity of the donor site was performed through Colour flow Doppler ultrasonography. Platelet rich plasma had the supreme advantage as it offered a multiple synergistically working growth factors that promoted mitogenesis of mesenchymal cells at the wound site. Growth factors viz., transforming growth factor-b, platelet derived growth factor and vascular endothelial growth factor were released after platelet degranulation led to fibroblast recruitment, proliferation and matrix remodelling which ultimately leads to good granulation tissue formation and wound healing in the cases.


Keywords: Platelet rich plasma, recipient wound bed, skin flap, dogs
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How to cite this article:

Gokulakrishnan. M, L. Nagarajan and Ramani. C. R. 2020. Preparation of Recipient Wound Bed by Platelet Rich Plasma for Skin Flaps in Dogs.Int.J.Curr.Microbiol.App.Sci. 9(3): 954-961. doi: https://doi.org/10.20546/ijcmas.2020.903.112