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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(2): 2415-2425
DOI: https://doi.org/10.20546/ijcmas.2020.902.275


Host Pathogen Interaction-Mycobacterium and Host Macrophages
Shalini Sharma* and Gursimran Filia
Animal disease research centre, GADVASU, Ludhiana, 141012, Punjab, India
*Corresponding author
Abstract:

Mycobacterium tuberculosis (MTB) is an intracellular parasite that mainly attacks macrophages and establish a niche to survive in macrophages. It can become a long-term infection in humans and animals, causing a series of pathological changes and clinical manifestations. In this article, we summarizes how mycobacterium evades innate immunity and establish a niche in the host cell macrophages. Firstly it evades from the immune detection by masking, it manipulates the TLR response, manipulation of the antigen presentation by MHC, inhibition of phagosomal maturation in which Iron, Hydrogen and Calcium ions down regulation play an important role and phagosomally sosomal fusion, Inhibition of acidification of Phagolysosomes, Inhibition of Oxidative Stress and the Function of Reactive Oxygen and Reactive Nitrogen Intermediates, and inhibition of the apoptosis and autophagy of macrophages. A thorough understanding of this host pathogen interaction and thus immune escape of Mycobacterium an intracellular pathogen is of major importance for the prevention and diagnosis of bovine tuberculosis.


Keywords: MTBC, TLR, MHC, Macrophages, Granuloma
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How to cite this article:

Shalini Sharma and Gursimran Filia. 2020. Host Pathogen Interaction-Mycobacterium and Host Macrophages.Int.J.Curr.Microbiol.App.Sci. 9(2): 2415-2425. doi: https://doi.org/10.20546/ijcmas.2020.902.275