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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(2): 2150-2171
DOI: https://doi.org/10.20546/ijcmas.2020.902.244


Immunological Host Responses Against Mycobacterium tuberculosis and M. bovis Infection: A Review
Varun Bassessar1, Nitasha Sambyal2, Rahul Singh1*, Mahesh Vishwas Chaudhari3, Vipan Kumar4, Rinmuanpuli Ralte4, Bharat Mengi5 and Shagufta Azmi1
1Department of Veterinary Pathology, Khalsa College of Veterinary and Animal Sciences, Amritsar (143002), India
2Department of Veterinary Public Health and Epidemiology, Khalsa College of Veterinary and Animal Sciences, Amritsar (143002), India
3Department of Animal Genetic and Breeding, Khalsa College of Veterinary and Animal Sciences, Amritsar (143002), India
4Department of Veterinary Microbiology, Khalsa College of Veterinary and
Animal Sciences, Amritsar (143002), India
5Obihiro University of Agriculture and Veterinary Medicine (OUAVM), Hokkaido, Japan
*Corresponding author
Abstract:

The immune response against tuberculosis (TB) plays a fundamental role in the outcome of Mycobacterium tuberculosis (Mtb) and M. bovis (Mbs) infection. The host’s innate immune cells such as macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells interact with Mtb and Mbs. And as such express a variety of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), Nod-like receptors (NLRs) and C-type lectin receptors (CLRs). All these receptors have been implicated in the recognition and uptake of Mtb and Mbs by various innate immune defense-associated cellular functions, such as phagocytosis, autophagy, apoptosis and inflammasome activation. In view of this, the present review article provides an updated overview and a better understanding of the cellular and molecular immune mechanisms underlying host-pathogen interactions that could provide a rational basis for the development of effective anti-TB therapeutics and diagnosis of the disease.


Keywords: Tuberculosis, host-pathogen, immune response, receptors
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How to cite this article:

Varun Bassessar, Nitasha Sambyal, Rahul Singh, Mahesh Vishwas Chaudhari, Vipan Kumar, Rinmuanpuli Ralte, Bharat Mengi and Shagufta Azmi. 2020. Immunological Host Responses Against Mycobacterium tuberculosis and M. bovis Infection: A Review.Int.J.Curr.Microbiol.App.Sci. 9(2): 2150-2171. doi: https://doi.org/10.20546/ijcmas.2020.902.244