National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Antibacterial activity of six different species of fungal extracts viz., Aspergillus ochraceous, Paecilomyces variotii, Schizophyllum sp., Epicoccum sp., Metarhizium sp., Aspergillus niger were evaluated against ten serotypes of Bacillus thuringiensis to develop new bioactive secondary metabolites from the microbial sources. Fungal crude extracts were isolated by ethyl acetate solvent extraction method and product yields varied from 0.150g to 0.538g. Thin Layer Chromatography was carried out for detecting the small molecule compounds present in the crude extracts. Antibacterial activities of fungal extracts were analyzed by disc diffusion method. All ten B.t serotypes were inhibited by six fungal extracts with zone of inhibition ranging from 12 ± 1.73 to 36 ± 1.53. Among the six extracts Paecilomyces variotii showed highest inhibition of 36 mm against B.t sotto. In vitro and in vivo studies conducted for the effect of extracts with different concentration and exposure duration reveals that effective against all serotypes. The results suggested that the Microbial derived extracts could be a new source of alternative in developing an effective bioactive molecule for the management of silkworm bacterial diseases.
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