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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(2): 1363-1371
DOI: https://doi.org/10.20546/ijcmas.2020.902.159


Prevalence of Carbapenem Resistance in Nonfermenting Gram Negative Bacteria in Patients with Respiratory Tract Infection Admitted in Intensive Care Units in Tertiary Care Centre
Seematai Prakash Katole and Nilekar Sandeep Laxmikant*
Department of Microbiology, Swami Ramanand Tirth Rural Govt. medical college and hospital, Ambajogai, Di.Beed, 431517, India
*Corresponding author
Abstract:

Most common bacterial agents of Lower Respiratory Tract Infection in the Intensive Care Units are Pseudomonas, Acinetobacter, Klebsiella, Citrobacter; which are multi drug resistant, and with limiting the therapeutic options.Nonfermenting Gram-negative bacilli are known to produce Extended spectrum β-lactamases (ESBLs) and metallo β-lactamases. Pseudomonas aeruginosa and Acinetobacter spp. in particular are most often associated with carbapenem resistance. The antimicrobial susceptibility testing of non-fermenting gram negative isolates was done by Kirby Bauer disc diffusion method according to CLSI 2019 (Clinical Laboratory Standards Institute) guidelines. Out of total 227gram negative isolates, nonfermenting gram negative bacteria were 118. out of 118, 76 were Pseudomonas aeruginosa and 42 were Acinetobacter baumannii. Out of total 76 isolated Pseudomonas aeruginosa, 33(43.42%) were resistant to imipenem and 22(28.94%) were resistant to meropenem. Out of total 42 isolated Acinetobacter baumannii,16(38.10%) were resistant to imipenem and 11(26.19%) were resistant to meropenem. In view of carbapenem resistance amongst the isolates, antibiotic therapy should be advocated or modified following culture and sensitivity. This would not only help in the proper treatment of the patient but also would discourage the indiscriminate use of available antibiotics and stop the spread of drug resistance bacteria.


Keywords: nonfermenting gram negative bacilli; carbapenem; Pseudomonas aeruginosa, Acinetobacter baumannii;
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How to cite this article:

Seematai Prakash katole and Nilekar Sandeep Laxmikant. 2020. Prevalence of Carbapenem Resistance in Nonfermenting Gram Negative Bacteria in Patients with Respiratory Tract Infection Admitted in Intensive Care Units in Tertiary Care Centre. Int.J.Curr.Microbiol.App.Sci. 9(2): 1363-1371. doi: https://doi.org/10.20546/ijcmas.2020.902.159