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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(2): 1196-1204
DOI: https://doi.org/10.20546/ijcmas.2020.902.141


Effects of Fermentation Conditions on the Production of
Secondary Metabolites of Penicillium brevicaule alba-CC200 and
Aspergillus egypticus–HT166 Inhibiting Pancreatic α-Amylase
G. Gulyamova, D. M. Ruzieva, S. M. Nasmetova,
I. Muhammedov, G. A. Rasulova and R. S. Sattarova*
Department of Biochemistry and Biotechnology of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, Uzbekistan
*Corresponding author
Abstract:

Carbon and nitrogen sources were selected to create a new modified Chapek-Doks nutrient medium in order to increase the production of secondary metabolites, that inhibit pancreatic α-amylase, by endophytic fungi Penicilliumbrevicaule alba-CC200 and Aspergillus egypticus-HT166. The results showed that the highest α-amylase inhibitory activity - 96.8% and 88%, respectively, was observed during the shake flask cultivation of strains at the end of the stationary  phase on a medium containing  casein supplemented by yeast extract.


Keywords: Endophytic fungi, α-amylase, Inhibitory activity, Secondary metabolites
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How to cite this article:

Gulyamova, T. G., D. M. Ruzieva, S. M. Nasmetova, I. I. Muhammedov, G. A. Rasulova and Sattarova, R. S. 2020. Effects of Fermentation Conditions on the Production of Secondary Metabolites of Penicillium brevicaule alba-CC200 and Aspergillus egypticus–HT166 Inhibiting Pancreatic α-Amylase. Int.J.Curr.Microbiol.App.Sci. 9(2): 1196-1204. doi: https://doi.org/10.20546/ijcmas.2020.902.141