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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(1): 853-857
DOI: https://doi.org/10.20546/ijcmas.2020.901.094


Comparison of in vitro Activities of Ceftazidime-Tazobactam, Piperacillin-Tazobactam, and Cefoperazone-Sulbactam and the Implication on Therapy in a Tertiary Care Teaching Hospital
Subbalakshmi1*, H. Kalavathy Victor1 and K. Loganathan2
1Department of Microbiology, 2Department of Surgery, ACS Medical College and Hospital, Chennai, Tamil Nadu, India
*Corresponding author
Abstract:

Resistance in pathogenic bacteria against antibiotics is a challenge for our clinicians for the management of various infections. The emergence of antibiotic resistance has caused great concern among health professionals and the prevalence of multidrug-resistant organisms has been increasing. Over-ambitious use of broad spectrum antibiotics is playing an important role in the increased incidence of infections due to MDR bacteria. Multiple drug resistance (MDR) mediated through R plasmids among Gram-negative bacteria has become a major nosocomial problem worldwide. Broad-spectrum β-lactams, such as imipenem, cefdinir, cefepime and cefpirome, and β-lactamase inhibitor combinations, such as piperacillin/tazobactam, cefoperazone/sulbactam and ticarcillin/clavulanate have been introduced in the market to overcome this resistance. Aim: To compare the antibiotic sensitivity of piperacillin/tazobactam, ceftazidime/tazobactam and cefoperazone/ sulbactam for gram negative isolates in our institute from various samples received in the hospital. This study was aimed at identifying the possible etiologic agents and determining their antibiotic sensitivity pattern, thereby allowing formulation of a reasonable initial empirical therapy regimen. OBJECTIVE: To choose the optimal antibiotic as the treatment for our patients who are developing infections. Overall, the sensitivity to ceftazidime/tazobactum was much higher compared to cefoperazone/sulbactum, piperacillin/tazobactum. The sensitivity was observed in medical wards for CAZ/TAZ (81.3%), CFS/SUL (49%), PIP/TAZ (47.4%), whereas in surgical wards the sensitivity observed was CAZ/TAZ (66%), CFS/SUL (32%), PIP/TAZ (27%) respectively. The sensitivity to Enterobacteriaceae group was CAZ/TAZ (69.3%), CFS/SUL (67%), PIP/TAZ (59%). The sensitivity to non-fermenters were CAZ/TAZ (31%),CFS/SUL (33%), PIP/TAZ (41%). Among non-fermenters, the sensitivity to PIP /TAZ (41%) was much better than CAZ/TAZ. Beta lactam inhibition combinations are used more in surgical patients than medical patients and the sensitivity to these combination drugs decreases with increased usage which clearly shows multidrug resistant pattern of organism. This can be prevented by following antibiotic policy and hand hygiene practice to avoid multidrug resistant organisms.


Keywords: Ceftazidime-Tazobactam, Piperacillin-Tazobactam and Cefoperazone-Sulbactam
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How to cite this article:

Subbalakshmi, E., H. Kalavathy Victor and Loganathan, K. 2020. Comparison of in vitro Activities of Ceftazidime-Tazobactam, Piperacillin-Tazobactam, and Cefoperazone-Sulbactam, and the Implication on Therapy in a Tertiary Care Teaching Hospital.Int.J.Curr.Microbiol.App.Sci. 9(1): 853-857. doi: https://doi.org/10.20546/ijcmas.2020.901.094