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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(12): 1439-1452
DOI: https://doi.org/10.20546/ijcmas.2019.812.174


Microbial Production of Antimicrobial Agents
Bassma H. Elwakil1*, Mahmoud M. Abdelaziz2, Kareem M. Mahgoub2,
Ahmed M. Abdelrasheed2, Ahmed N. Ameen2and Zakia A. Olama2
1Department of Allied Medical Science, Pharos University in Alexandria, Egypt
2Department of Botany and Microbiology, Faculty of Science, Alexandria, Egypt
*Corresponding author
Abstract:

In a trial to search for a new antibiotic producer a terrestrial actinomycete was isolated from AL-alameen soil which proved to be a potential candidate for the production of active metabolites against E. coli 25922 and Staphylococcus aureus 25923. It was identified phenotypicallyas Streptomyces sp. The optimum activity was obtained when the organism was grown on glycerol as a sole carbon source at 30°C and pH 7.0 for 192 h. The highest metabolic activity noticed intracellulary and it was approved with MIC values. In a trial to test the combined activity of the extract and some antibiotics; synergistic action was noticed with ceftriaxone. Further investigations were applied to the extract for its active components using TLC and GC-MS which indicated that Pentadecanoic acid, 14-methyl-, methyl ester; Hexadecanoic acid, methyl ester and 2,4-bis(1,1-dimethylethyl)- Phenol were the potent active components. Toxicity test will be evaluated for the active components as well as the crude extract.


Keywords: Pentadecanoic acid, 14-methyl- methyl ester, Hexadecanoic acid
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How to cite this article:

Bassma H. Elwakil, Mahmoud M. Abdelaziz, Kareem M. Mahgoub, Ahmed M. Abdelrasheed, Ahmed N. Ameen and Zakia A. Olama. 2019. Microbial Production of Antimicrobial Agents.Int.J.Curr.Microbiol.App.Sci. 8(12): 1439-1452. doi: https://doi.org/10.20546/ijcmas.2019.812.174