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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(11): 2175-2188
DOI: https://doi.org/10.20546/ijcmas.2019.811.252


Detection of Zoonotic Rotavirus Transmission involving a Rare Genotype G3P[3] in the Amazon Region: A Phylodynamic Approach with Multiple Events of Reassortment and Evolutionary Origin
Renato da Silva Bandeira1, Lizandra Caroline dos Santos Souto1, Layse Costa de Souza1, Delana Andreza Melo Bezerra2, Poliana da Silva Lemos2, Alexandre C. Linhares2 and Joana D'Arc Pereira Mascarenhas2*
1Department of Virology, Evandro Chagas Institute, Ananindeua-Pará-Brazil
2Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua-Pará-Brazil
*Corresponding author
Abstract:

Rotaviruses of the species A (RVA) are of particular epidemiological importance and recognized as being worldwide dispersed. RVA causes the majority of infections in humans, as well as are highly prevalent among domestic animals. Several studies have shown that zoonotic transmission may occur from animals to humans and this may account for the current broad antigenic and genetic rotavirus diversity, representing a potential important evolutionary mechanism. The present study aims to identify the evolutionary origins of circulating RVA strains in the Amazon region, using phylodynamics methods to assess and understand the relationship between hosts, inter-specific gene transfer and the chronology of viral infection. In total 83 RVA-positive faecal samples of human origin were analyzed, all of which obtained within the official Rotavirus Epidemiological Surveillance Network in Brazil. The genome of 17 RVA samples were selected and sequenced. Eight RVA strains of zoonotic origins were identified. Of the five G4P[6] genotype samples were shown to be of porcine origin, and two samples were generated from reassortment events involving genotypes of human and porcine strains. One sample of G3P[3] genotype strain, identify as lineage III, have evolved from canine, feline or simian origin, including a reassortment event with RVA strains from lineage II. In addition, G12P[9] strains had their origins in chiroptera, cattle or felines. The present study included phylodynamic analyses in order to elucidate those otherwise unknown evolutionary patterns, mainly in regards to G3P[3] and G12P[9] genotypes. There was a particular focus on the occurrence of reassortment events and the evolutionary mechanism which underlie the emergence of these strains. These evolutionary events may help in the monitoring of emergent strains of RVA with zoonotic potential and vaccine-escape possibility.


Keywords: Rotavirus A, Zoonotic, Rare, Phylodynamic, Amazon
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How to cite this article:

Renato da Silva Bandeira, Lizandra Caroline dos Santos Souto, Layse Costa de Souza, Delana Andreza Melo Bezerra, Poliana da Silva Lemos, Alexandre C. Linhares and Joana D'Arc Pereira Mascarenhas. 2019. Detection of Zoonotic Rotavirus Transmission involving a Rare Genotype G3P[3] in the Amazon Region: A Phylodynamic Approach with Multiple Events of Reassortment and Evolutionary Origin.Int.J.Curr.Microbiol.App.Sci. 8(11): 2175-2188. doi: https://doi.org/10.20546/ijcmas.2019.811.252