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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(11): 801-806
DOI: https://doi.org/10.20546/ijcmas.2019.811.094


Prevalence of Extended Spectrum of Beta Lactamase (ESBL) Producing Uropathogens from Pregnant Women in a Tertiary Care Hospital
Sudhir Joshilkar and Madhumati Patil*
Department of Microbiology, KAHER, Jawaharlal Nehru Medical College, Belagavi, Karnataka, India
*Corresponding author
Abstract:

Urinary tract infection (UTI) represents the most common bacterial infection in pregnancy. Urinary tract infection poses a serious health threat because of the antibiotic resistance and high recurrence rate. Extended Spectrum Beta-Lactamases (ESBLs) producing Enterobacteriaceae are among the most problematic multidrug resistant bacteria worldwide and are increasingly causing urinary tract infection both in hospitalized patients and outpatients making infections difficult to treat. This study was undertaken to identify the changing etiological trends of urinary tract infections (UTI), detect the prevalence of ESBL producing Uropathogens and study their antibiotic resistance profile. Urinary isolates from symptomatic UTI cases were identified by conventional methods. Antimicrobial susceptibility testing was done by Kirby Bauer’s disc diffusion method. Isolates resistant to cephotaxime were tested for ESBL production by double disc synergy test method. Total 6 ESBL producing organisms were isolated out of 54-gram negative bacilli among 170 urine samples of pregnant women. The most predominant ESBL producing isolates were Escherichia coli (37.5%), followed by Citrobacter frundii (25.0%) and Klebsiella pneumoniae (12.5%). The antibiogram pattern of ESBL producing isolates showed maximum sensitivity to Imipenem (75.0%), Meropenem (75.0%) and Gentamicin (62.5%). This study shows that the Prevalence rate of ESBL producing E. coli and Citrobacter freundii is high in pregnant women. Most of the ESBL producing isolates were multidrug resistant. Careful detection of ESBL production and antimicrobial susceptibility testing are necessary to avoid treatment failure in patients with UTI.


Keywords: Urinary tract infection, Extended Spectrum Beta Lactamase, Uropathogens
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How to cite this article:

Sudhir Joshilkar and Madhumati Patil. 2019. Prevalence of Extended Spectrum of Beta Lactamase (ESBL) Producing Uropathogens from Pregnant Women in a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 8(11): 801-806. doi: https://doi.org/10.20546/ijcmas.2019.811.094