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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(11): 941-949
DOI: https://doi.org/10.20546/ijcmas.2019.811.110


Protective Role of Ashwagandha and Selenium against Chlorpyrifos (CPF) Induced Haemato-Biochemical and Hepatic Alterations in Wistar Rats
Vellanki Manvitha1*, A. Gopala Reddy2, B. Anil Kumar1, M. Jeevanalathaand G. Priyanka1
1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India
2Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial-505326, India
3Department of Veterinary Pathology, College of Veterinary Science, Mamnoor, Warangal-506166, India
*Corresponding author
Abstract:

The present experiment was detailed about the protective effect of Ashwagandha and selenium on chlorpyrifos (CPF) induced changes in haemato-biochemical parameters and liver histology in rats. 42 male albino Wistar rats were procured and divided into 7 groups consisting of 6 in each. Group 1- Normal Control. Group 2 - Chlorpyrifos(@ 2.5 mg/kg body weight/p.o./day). Group 3 – Ashwagandha (@ 100 mg/kg body weight/p.o./day). Group 4 – Selenium (@ 10 µg/kg body weight/p.o./day). Group 5 – Chlorpyrifos (@ 12.5 mg/kg body weight/p.o./day) + Ashwagandha (@ 100 mg/kg body weight/p.o./day). Group 6 – Chlorpyrifos (@ 12.5 mg/kg body weight/p.o./day) + Selenium (@ 10 µg/kg body weight/p.o./day). Group 7 – Chlorpyrifos(@ 12.5 mg/kg body weight/p.o./day) + Ashwagandha (@ 100 mg/kg body weight/p.o./day) + Selenium (@ 10 µg/kg body weight/p.o./day). Group 7 rats revealed a significant (P<0.05) increase in the mean values of total erythrocyte count (TEC), total leucocyte count (TLC), haemoglobin (Hb) concentration and packed cell volume (PCV) and a significant (P<0.05) decrease in aspartate amino transferase (AST) and alanine transaminase (ALT) and rejuvenated hepatic parenchyma when compared to group 2 rats. These results suggested that the administration of Ashwagandha and selenium offered remarkable synergistic protective action against CPF induced alterations in haemato-biochemistry and histology.


Keywords: Chlorpyrifos, Ashwagandha, Selenium, Haematology, Serum biochemistry, Oxidative stress
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How to cite this article:

Vellanki Manvitha, A. Gopala Reddy, B. Anil Kumar, M. Jeevanalatha and Priyanka, G. 2019. Protective Role of Ashwagandha and Selenium against Chlorpyrifos (CPF) Induced Haemato-Biochemical and Hepatic Alterations in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 8(11): 941-949. doi: https://doi.org/10.20546/ijcmas.2019.811.110