National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present experiment was detailed about the protective effect of Ashwagandha and selenium on chlorpyrifos (CPF) induced changes in haemato-biochemical parameters and liver histology in rats. 42 male albino Wistar rats were procured and divided into 7 groups consisting of 6 in each. Group 1- Normal Control. Group 2 - Chlorpyrifos(@ 2.5 mg/kg body weight/p.o./day). Group 3 – Ashwagandha (@ 100 mg/kg body weight/p.o./day). Group 4 – Selenium (@ 10 µg/kg body weight/p.o./day). Group 5 – Chlorpyrifos (@ 12.5 mg/kg body weight/p.o./day) + Ashwagandha (@ 100 mg/kg body weight/p.o./day). Group 6 – Chlorpyrifos (@ 12.5 mg/kg body weight/p.o./day) + Selenium (@ 10 µg/kg body weight/p.o./day). Group 7 – Chlorpyrifos(@ 12.5 mg/kg body weight/p.o./day) + Ashwagandha (@ 100 mg/kg body weight/p.o./day) + Selenium (@ 10 µg/kg body weight/p.o./day). Group 7 rats revealed a significant (P<0.05) increase in the mean values of total erythrocyte count (TEC), total leucocyte count (TLC), haemoglobin (Hb) concentration and packed cell volume (PCV) and a significant (P<0.05) decrease in aspartate amino transferase (AST) and alanine transaminase (ALT) and rejuvenated hepatic parenchyma when compared to group 2 rats. These results suggested that the administration of Ashwagandha and selenium offered remarkable synergistic protective action against CPF induced alterations in haemato-biochemistry and histology.
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