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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(11): 314-320
DOI: https://doi.org/10.20546/ijcmas.2019.811.039


The Toxic Effects of Paraquat (PQ) on Body Weights and Haematological Parameters in Male Albino Wistar Rats and its Amelioration with Vitamin C
Kothinti Busa Ashok Kumar Reddy1*, M. Jeevanalatha2, M. Lakshmanand M. Usha Rani1
1Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India
2Department of Veterinary Pathology, College of Veterinary Science, Mamnoor, Warangal-506166, India
*Corresponding author
Abstract:

The present experiment was carried out to investigate the protective effect of Vitamin C on body weights and haematological parameters following paraquat (PQ) intoxication in rats. Total of 48 male albino Wistar rats were procured and divided into 4 groups consisting of 12 in each. Group 1- Control. Group 2 - Paraquat (PQ) at the rate of 40 milligram/kg body weight/per oral/day. Group 3 - Vitamin C at the rate of250 milligram/kg body weight/per oral/day. Group 4 - paraquat (PQ) at the rate of 40 milligram/kg body weight/per oral/day + Vitamin C at the rate of 250 milligram/kg body weight/per oral/day. The experiment was carried out for a period of 21 days. Group 4 rats revealed a significant (P<0.05) increase in the mean values of body weights, erythrocyte indices, total erythrocyte count (TEC), total leucocyte count (TLC) and Hb concentration except packed cell volume (PCV) which was insignificant when compared with group 2 rats. These results suggested that the Vitamin C administration offered remarkable protection against PQ induced alterations in body weights and haematology.


Keywords: Paraquat, Vitamin C, Body weights, Haematology, Multiple organ failure, Albino wistar rats
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How to cite this article:

Kothinti Busa Ashok Kumar Reddy, M. Jeevanalatha, M. Lakshman and Usha Rani, M. 2019. The Toxic Effects of Paraquat (PQ) on Body Weights and Haematological Parameters in Male Albino Wistar Rats and its Amelioration with Vitamin C.Int.J.Curr.Microbiol.App.Sci. 8(11): 314-320. doi: https://doi.org/10.20546/ijcmas.2019.811.039