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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(10): 2558-2565
DOI: https://doi.org/10.20546/ijcmas.2019.810.296


Adaptogenic (Anti-Stress) Effect of Aqueous Musanga cecropioides (Urticaceae)
Tunde A. Owolabi1,2*, K.C. Ezenwa1, E.Y. Olayioye1, O.C. Iyorhibe1, E. Amodu1, O.F. Aferuan1, P.C. Okubor3, B.A. Ayinde2 and J.I. Okogun1
1Research Unit, Paxherbal Clinic and Research Laboratories, Edo state, Nigeria
2Pharmacognosy department, University of Benin, Benin City, Edo State, Nigeria
3Department of Biology, College of Education, Agbor, Delta state, Nigeria
*Corresponding author
Abstract:

Everyone tries to relieve stress by taking anti-stress drugs. However, synthetic anti-stress drugs have unwanted side effects, expensive and not readily accessible. Thus, we aimed at investigating the anti-stress activities of aqueous extract of Musanga cecropioides stem bark using forced swimming endurance stress test, anoxia stress tolerance, chronic cold resistance stress test and DPPH radical scavenging capacity. Daily administration of aqueous extract of M. cecropioides at doses of 100, 200 and 300mg/kg bodyweight one hour prior to induction of stress, at the lowest dosage (100 mg/kg)significantly increased the anoxia stress and forced swimming endurance stress tolerance times in a dose dependent manner as compared to the control groups (46.48±0.28 and 3.01±0.92 compared 28.80±0.38 and 2.25±0.08 mins), the blood glucose, blood cells, and the urinary ascorbic acid were normalised in all the tested methods including chronic cold stress. The extract also scavenged DPPH significantly in a dose dependent manner. The results showed impressive anti-stress potential and present as far as is known, the first report of the anti-stress (adaptogenic) activities of M. cecropioides.


Keywords: Anti-stress, Anti-oxidant, Musanga cecropioides
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How to cite this article:

Tunde A. Owolabi, K.C. Ezenwa, E.Y. Olayioye, O.C. Iyorhibe, E. Amodu, O.F. Aferuan, P.C. Okubor, B.A. Ayinde and Okogun, J.I. 2019. Adaptogenic (Anti-Stress) Effect of Aqueous Musanga cecropioides (Urticaceae).Int.J.Curr.Microbiol.App.Sci. 8(10): 2558-2565. doi: https://doi.org/10.20546/ijcmas.2019.810.296