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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(2): 922-932
DOI: http://dx.doi.org/10.20546/ijcmas.2017.602.103


Replacement of Inorganic Zinc with Various Organic Zinc Sources on Haematological Constituents, Antioxidant Status, Immune Response and Reproductive Efficiency in Rats
D. Nagalakshmi1, K. Sadasiva Rao2, G. Aruna Kumari3, S.Parashuramulu4 and K. Sridhar5*
1College of Veterinary Science, Rajendranagar, Hyderabad, Telanagana -500 030, India
2College of Veterinary Science, Gannavaram, Andhra Pradesh, India
3Department of Veterinary Gynaecology and Obstetrics, College of Veterinary Science, Rajendranagar, Hyderabad, Telanagana, India
 4Chalimeda feeds Pvt Ltd, Karimnagar, Telangana, India
5Department of Animal Nutrition, College of Veterinary Science, Rajendranagar
Hyderabad, Telanagana -500 030, India
*Corresponding author
Abstract:

The present study was undertaken on 60 adult female Sprague Dawley rats (275±2.04 g) for an experimental duration of 84 days to evaluate various organic sources of zinc on immunity, reproduction, oxidative defense mechanism in rats. The rats were randomly allotted to 5 dietary treatments (6 replicates in each) prepared by varying the source of Zn supplementation (12 ppm) either from inorganic (Zn carbonate) or sources (Zn proteinate, Zn propionate, Zn amino acid complex and Zn methionine). Supplementation of organic zinc had no significant effect on performance, haematological and serum biochemical parameters, TBARS and protein carbonyls concentration in liver. The glutathione reductase activity (P<0.05) in haemolysate and reduced glutathione concentration in liver (P<0.01) was higher in organic Zn fed rats, while highest (P<0.01) RBC catalase activity was noticed with Zn methionine supplementation. The humoral immune response against sheep RBC was increased (P<0.05) with organic Zn supplementation. The cell mediated immune response was higher (P<0.05) in Zn propionate group. The serum progesterone concentration was higher (P<0.05) in rats fed organic Zn sources. Organic Zn supplementation increased (P<0.05) the number of graafian follicles and corpus luteum. The study indicated that supplementing 12 ppm of Zn from various organic sources had higher antioxidant enzyme activities, immune response and serum progesterone concentration with higher number of mature follicles in ovaries compared to inorganic.


Keywords: Folliculogenesis, Immunity, Organic zinc, Oxidative stress, Progesterone.
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How to cite this article:

Nagalakshmi, D., K. Sadasiva Rao, G. Aruna Kumari, S. Parashuramulu and Sridhar, K. 2017. Replacement of Inorganic Zinc with Various Organic Zinc Sources on Haematological Constituents, Antioxidant Status, Immune Response and Reproductive Efficiency in RatsInt.J.Curr.Microbiol.App.Sci. 6(2): 922-932. doi: http://dx.doi.org/10.20546/ijcmas.2017.602.103