National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Bloodstream infections are frequent and life – threatening, can lead to increase in morbidity, mortality and health care cost of patients admitted in intensive care unit (ICU). In addition to this, infections due to emerging multidrug resistant (MDR) microorganisms, the treatment becomes challenging. With the rising problem of drug resistance, the present study was undertaken to evaluate the most prevalent bacterial pathogen causing Bloodstream infections in adult patients admitted to an Intensive Care Unit (ICU) with their antimicrobial sensitivity pattern. A retrospective analysis of data was done on the blood cultures received from 817 patients with clinically suspected bloodstream infections, admitted in Medical ICU of tertiary care hospital, Navi Mumbai, between October 2016 and October 2018. All the samples were received and processed in the Department of Microbiology, using standard microbiological techniques and antimicrobial sensitivity was done according to CLSI guidelines. From 817 patients, the positive growth for pathogen was observed in 165 (20.19%) patients. 167 isolates were identified, maximum isolates were Gram – negative 120 (71.86%), Gram – positive were 31 (18.56%) and Candida spp. were 16 (9.58%). Among bacterial isolates, there was a predominance of Klebsiella pneumoniae 37 (22.15%) followed by Acinetobacter spp. 31 (18.56%), Escherichia coli 29 (17.36%), Pseudomonas aeruginosa 16 (9.58%) &Enterococcus spp. 14 (8.38%). Gram – negative bacterial pathogens showed decreasing sensitivity to Imipenem, Piperacillin – tazobactum, Aminoglycosides, Third – generation Cephalosporins& Cephalosporin. Whereas all gram – positive bacterial isolates were sensitive to Vancomycin and Linezolid while resistant to Penicillin. This study showed the high prevalence of multi drug resistant gram – negative pathogens causing bloodstream infections in our ICU setting. Thus a continues surveillance of prevalent etiological pathogens of BSI along with their antibiotic susceptibility pattern will be helpful to the clinicians in choosing the proper antimicrobials. And clinical management of BSI will minimize the emergence of multi drug resistance.
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