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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(8): 1019-1028
DOI: https://doi.org/10.20546/ijcmas.2019.808.118


Effect of Cholesterol and Niacin Supplementation on Serum Lipid Profile in Experimentally Induced Renal Dysfunction in Wistar Rats
Pallavi Khajuria1*, Pratiksha Raghuwanshi1, Aditi Lal Koul1, Ankur Rastogi2, Dibyendu Chakarborty3, Vishav Pratap Singh4, Sumeet Kour1 and V.S. Wazir5
1Division of Veterinary Physiology and Biochemistry, FVSc & AH, SKUAST-J, R S Pura, 181102, Jammu, India
2Division of Animal Nutrition, FVSc & AH, SKUAST-J, R S Pura, 181102, Jammu, India
3Division of Animal Genetics & Breeding, FVSc & AH, SKUAST-J, R S Pura, 181102, Jammu, India
4Department of Animal Husbandry, Jammu & Kashmir State, J&K, India
5Division of veterinary Medicine, FVSc & AH, SKUAST-J, R S Pura, 181102, Jammu, India
*Corresponding author
Abstract:

Study was conducted on 84 adult male Wistar rats for a duration of sixty days. Animals were divided into twelve equal groups and treatments were applied as 2x3x2 factorial design with 2 renal conditions (Normal and Compromised); 3 cholesterol supplementation levels (0%, 0.5% and 1% w/w on DM basis) and 2 niacin supplementation levels (Unsupplemented and Supplemented @ 100 mg/kg body weight per day orally). Renal dysfunction was induced in respective groups by daily intra-peritoneal injection of gentamicin @ 80mg/kg body weight for 8 days. Blood samples were collected on 0th, 20th, 40th and 60th day of experiment to study lipid profile. Renal dysfunction as well as cholesterol supplementation resulted in significant (p<0.01) elevation of total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-c), very low density lipoprotein (VLDL-c) and a significant lowering of high density lipoprotein (HDL-c) levels. Niacin Supplementation @ 100 mg/kg body weight, however led to significant improvement in lipid profile.


Keywords: Cholesterol, Lipid profile, Niacin, Renal dysfunction, Wistar rat
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How to cite this article:

Pallavi Khajuria, Pratiksha Raghuwanshi, Aditi Lal Koul, Ankur Rastogi, Dibyendu Chakarborty, Vishav Pratap Singh, Sumeet Kour and Wazir, V.S. 2019. Effect of Cholesterol and Niacin Supplementation on Serum Lipid Profile in Experimentally Induced Renal Dysfunction in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 8(8): 1019-1028. doi: https://doi.org/10.20546/ijcmas.2019.808.118