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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(8): 480-485
DOI: https://doi.org/10.20546/ijcmas.2019.808.055


Haematological Alterations Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Male Wistar albino Rats o
Yadala Ravikumar1*, D. Madhuri2, M. Lakshman1, A. Gopala Reddy3 and B. Kalakumar4
1Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India
2Department of Veterinary Pathology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, India
3Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, India
4Department of Pharmacology and Toxicology, C.V.Sc, Rajendranagar, Hyderabad-500030, India
*Corresponding author
Abstract:

The present study was aimed to know the haematological alteration due to individual toxicities of cadmium, chlorpyrifos and their combination in albino wistar rats. The experiment was carried out for 28 days. Group 1 - Control. Group 2 - Cadmium chloride (Cd) @ 22.5mg/ kg b.wt /per oral / day. Group 3 - Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. Group 4 - Cadmium chloride (Cd) @22.5 mg + Chlorpyrifos (CPF) @ 25 mg/ kg b.wt /per oral / day. The weekly body weight gains were significantly (P < 0.05) decreased in groups 4, 3 and 2 when compare with control group. Haematological observations revealed a significant (P < 0.05) decrease in overall means of TEC, Hb, PCV in except TLC in groups 4, 2 and 3 when compare with control group. TLC values were increased 4, 2 and 3. These results revealed that combined toxicity of cadmium and chlorpyrifos is significant than exposure of individual components which resulted in alterations in haematological parameters.


Keywords: Haematology, Cadmium, Chlorpyrifos and Wistar albino rats
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How to cite this article:

Yadala Ravikumar, D. Madhuri, M. Lakshman, A. Gopala Reddy and Kalakumar, B. 2019. Haematological Alterations Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Male Wistar albino Rats.Int.J.Curr.Microbiol.App.Sci. 8(8): 480-485. doi: https://doi.org/10.20546/ijcmas.2019.808.055