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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 910-916
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.107


Antiretroviral Therapy that Includes, Protease Inhibitors - Induced Hepatotoxicity: A Review
V.S. Chopra1, Mani Goel2*, Jyoti Batra3, Jyotsna Sharma4 and Kavita Dhar4
1Department of Pharmacology, Santosh Medical College, Ghaziabad
2L.L.R.M, Medical College, Meerut, India
3Department of Biochemistry, Santosh Medical College, Ghaziabad, India
4Department of pharmacology, Santosh Medical College, Ghaziabad, India
*Corresponding author
Abstract:

Human immunodeficiency virus (HIV) is a retro virus known to be the primary aetiological agent of Acquired Immunodeficiency syndrome (AIDS). It is reported that about 39 million people globally are living with HIV. HIV infected patients are frequently present with elevated levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). This has been often attributed to the hepatic effects of Antiretroviral- Protease Inhibitor drugs (PI’s). A review of cohort studies investigating the incidence of hepatotoxicity among patients receiving Antiretroviral- Protease inhibitor drugs suggests that the overall rate of ALT and AST elevations is similar among all Protease inhibitor drugs and considering the importance of drug induced hepatotoxicity as major cause of liver damage, this review also throws light on protease inhibitor drugs which induce hepatotoxicity, with their mechanism of liver damage and clinical scenario.


Keywords: Protease Inhibitors,HIV,Antiretroviral Therapy.
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How to cite this article:

Chopra, V.S., Mani Goel, Jyoti Batra, Jyotsna Sharma and Kavita Dhar. 2017. Antiretroviral Therapy that Includes, Protease Inhibitors - Induced Hepatotoxicity: A Review.Int.J.Curr.Microbiol.App.Sci. 6(1): 910-916. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.107