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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(7): 1538-1548
DOI: https://doi.org/10.20546/ijcmas.2019.807.183


Vitamin E Ameliorates the Mineralo-Oxidative Stress of Sucking Lice Infestation in Indian Water Buffalo
E. Madhesh1*, Umesh Dimri1, Y. Ajith1, S. Shanmuganathan2, P. Sivasankar3, R. Karthikeyan4, Alok Kumar Choudhary1 and K. Kavitha1
1Division of Medicine
2Division of Virology,
3Division of Microbiology,
4Division of Biochemistry, ICAR-Indian Veterinary Research Institute, Izatnagar, UP, India-243122
*Corresponding author
Abstract:

Bubaline pediculosis is a common and economically important ectoparasitic condition caused by sucking lice, Haematopinus tuberculatus. This condition in buffalo is characterized by anemia, mineral imbalance, and loss of production performance but its pathobiology is explored less. Aim of the present study was to explore the mineralo-oxidaive pathobiology of bubaline pediculosis and its amelioration using the two antioxidants as an adjunct therapeutic modality (N- acetyl cysteine and Vitamin E). Twenty four buffaloes, severely infested with sucking lice (mean total lice count more than 100) were divided into three groups (Group I, II and III) with eight animals per group; another eight animals (Group IV) free from any clinical abnormalities and ectoparasitism were included as healthy control. Lice infested animals (Group I, II and III) animals were given ivermectin therapy (200 µg/kg body weight SC single dose); additionally, group II and group III animals were orally treated with N-acetyl cysteine (12 mg/kg body weight) and vitamin E (Tocopheryl acetate 4000 mg per animal), respectively, once daily for 14 days. The haematological parameters (TEC, Hb, TLC and DLC), oxidant-antioxidant profile (TAC, LPO, GSH, and SOD) and mineral profile (Zinc, Iron, Magnesium, and Copper) were studied on before therapy (Day 0) and post therapy (Day 28). Bubaline pediculosis revealed severe oxidative stress and mineral imbalance along with remarkable anaemia and leukocytosis. Vitamin E given animals demonstrated better recovery from the mineralo-oxidative pathology of bubaline pediculosis and approached post therapeutic normalcy. Vitamin E as an adjunct therapy along with ivermectin alleviated the patho-biological damages in the host system and speed up the clinical recovery, whereas, N-acetyl cysteine was less effective in quenching the mineralo-oxidative response. Future studies on antioxidants therapy may target the influence of mineralo-oxidative response in the host system.


Keywords: Vitamin E, Bubaline pediculosis, Oxidative stress, Mineral balance, N-acetyl cysteine
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How to cite this article:

Madhesh, E., Umesh Dimri, Y. Ajith, S. Shanmuganathan, P. Sivasankar, R. Karthikeyan, Alok Kumar Choudhary and Kavitha, K. 2019. Vitamin E Ameliorates the Mineralo-Oxidative Stress of Sucking Lice Infestation in Indian Water Buffalo.Int.J.Curr.Microbiol.App.Sci. 8(7): 1538-1548. doi: https://doi.org/10.20546/ijcmas.2019.807.183