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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 629-638
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.076


Seroprevalence of Helicobacter pylori and Chlamydia pneumoniae among Patients with Coronary Artery Diseases at Mansoura University Hospital, Egypt
Maysaa El Sayed Zaki1*, Nashwa M. Al-Kasaby2 and Mostafa Abd El Salam3
1Clinical Pathology Department, Faculty of Medicine, Mansoura University, Egypt
2Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt
3Internal Medicine Department, Faculty of Medicine, Mansoura University, Egypt
*Corresponding author
Abstract:

Coronary artery diseases (CAD) are a global health problem. Its etiology is associated with various risk factors like hypertension, diabetes mellitus (DM) and dyslipidemia. Infections may represent an additive risk factor. The aim of the present study was to investigate the seroprevalence of specific immunoglobulins G for Chlamydia pneumoniae (C. pneumoniae) and Helicobacter pylori(H. pylori)among Patients admitted in intensive Coronary Care Unit of Mansoura university hospital. This study included 80 patients previously diagnosed to have CAD according to medical records and electrocardiographic (ECG) changes. The second group compromised 80 healthy control subjects. Samples from each subject were subjected to full biochemical laboratory tests, including complete lipid profile. Enzyme-linked immunosorbentassay (ELISA) was done for immunoglobulin (IgG) antibodies to H. pylori and C. pneumonia. Multiple logistic regression analysis were used to find out statistically significant results for H. pylori IgG and C. pneumoniae IgG  and other conventional risk factors including; hypertension, diabetes, obesity and dyslipidaemia. Seroprevalence of specific IgG antibodies for C. pneumoniae and H. pylori showed significant increase in C. pneumoniae IgG and H. pylori IgG  positivity among patients compared to control ( P value  <0.001 and 0.015, respectively)  .Analysis of risk factors associated with CAD revealed a significant association of C. pneumoniae IgG (P<0.001) and no association of H. pylori IgG (P=0.07) with CAD. Our study showed significant association between seropositivity of H. pylori and C. pneumoniae and CAD. Risk factors analysis for CAD revealed significant associations of CAD with hypertension, Diabetes mellitus (DM) and C. pneumoniae IgG.


Keywords: CAD, Chlamydia pneumoniae, Helicobacter pylori, Coronary artery disease, Seroprevalence.
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How to cite this article:

Maysaa El Sayed Zaki, Nashwa M. Al-Kasaby, Mostafa Abd El Salam. 2017. Seroprevalence of Helicobacter pylori and Chlamydia pneumoniae among Patients with Coronary Artery Diseases at Mansoura University Hospital, Egypt.Int.J.Curr.Microbiol.App.Sci. 6(1): 629-638. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.076